{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:20:00Z","timestamp":1787606400424,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ziziphus lotus<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. is used in folk medicine for various ailments. This study investigated the potential protective effects of aqueous extracts from the fruit (ZLFAE) and leaves (ZLLAE) of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Z. lotus<\/jats:italic>\n                    <\/jats:styled-content>\n                    against testicular toxicity associated with Bisphenol A (BPA) exposure in a rat experimental model. ZLFAE and ZLLAE were characterized for the content of phytochemicals, showing high content in catechol, quercetin, and caffeic acid for ZLFAE associated with higher antioxidant capacity. Male Wistar rats were divided into six groups orally exposed to BPA (100\u2009mg\/kg), or BPA combined with ZLFAE (150 or 300\u2009mg\/kg) or ZLLAE (150 or 300\u2009mg\/kg) for 4\u2009weeks. In control animals (CTRL), exposure to BPA and treatments with ZLFAE or ZLLAE were omitted. Animals were then sacrificed and assessed for testis histology, semen parameters, antioxidant parameters, and oxidative stress biomarkers. Exposure to BPA was associated with reduced testis and epididymis weights, reduced serum testosterone and semen parameters, with increased markers of lipid peroxidation, oxidized thiols, and impaired catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activity. Treatment with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Z. lotus<\/jats:italic>\n                    <\/jats:styled-content>\n                    extracts, particularly ZLFAE 150\u2009mg\/kg, markedly mitigated these biochemical and structural alterations. These findings suggest that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ziziphus lotus<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. fruits exert protective effects likely due to their phenolic compounds with antioxidant properties, offering a potential protective potential towards BPA\u2010associated testicular toxicity.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71911","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T02:44:53Z","timestamp":1780022693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Role of\n                    <i>Ziziphus lotus<\/i>\n                    Fruits and Leaves Extracts Towards\n                    <scp>BPA<\/scp>\n                    \u2010Associated Testis Toxicity"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5650-6890","authenticated-orcid":false,"given":"Dhekra","family":"Grami","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bioresources\u2010Higher Institute of Biotechnology of Beja University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8475-7854","authenticated-orcid":false,"given":"Soumaya","family":"Wahabi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bioresources\u2010Higher Institute of Biotechnology of Beja University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-0628","authenticated-orcid":false,"given":"Raja","family":"Jouini","sequence":"additional","affiliation":[{"name":"Pathology Departement, Faculty of Medecine of 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