{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:20:33Z","timestamp":1787606433802,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["24CXGA097"],"award-info":[{"award-number":["24CXGA097"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chinese Kushui Rose (\n                    <jats:italic>Rosa sertata \u00d7 Rose rugosa<\/jats:italic>\n                    ) is widely recognized for its medicinal and edible properties, and Chinese Kushui Rose Essential Oil (KREO) has attracted growing attention due to its potential anxiolytic and sedative\u2010hypnotic effects. This study aims to systematically evaluate the preventive effects of KREO against depression\u2010like behaviors and explore its underlying mechanisms. We identified 57 volatile compounds from KREO using gas chromatography\u2013mass spectrometry (GC\u2013MS), with the major constituents being citronellol, geraniol, and citronellyl acetate. In mice with chronic unpredictable mild stress (CUMS)\u2010induced depression, administration of KREO facilitated body weight recovery, alleviated depressive\u2010like behaviors, and improved voluntary locomotor activity and exploratory behavior. Mechanistic investigations revealed that KREO increased hippocampal levels of serotonin (5\u2010HT) and brain\u2010derived neurotrophic factor (BDNF), reduced serum corticosterone (Cort) concentrations, and upregulated the expression of tyrosine receptor kinase B (TrkB) as well as the phosphorylation of extracellular signal\u2010regulated kinase 1\/2 (p\u2010ERK1\/2) in the hippocampus. Thus, KREO prevents depression\u2010like behavior by enhancing monoaminergic neurotransmission and attenuating hypothalamic\u2013pituitary\u2013adrenal (HPA) axis hyperactivity, with these effects associated with activation of the BDNF signaling pathway. These findings support the potential of KREO as a therapeutic intervention for depression and as a functional dietary ingredient.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71912","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:16:04Z","timestamp":1779880564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>KREO<\/scp>\n                    Prevents\n                    <scp>CUMS<\/scp>\n                    \u2010Induced Depressive\u2010Like Behavior via Modulation of the\n                    <scp>BDNF<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Yanni","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences Lanzhou University  Lanzhou 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