{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:21:18Z","timestamp":1787606478325,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cranberry polyphenols reach the colon largely unmetabolized, where they interact with the gut microbiota to generate bioactive metabolites. However, few human studies have examined both the microbial and systemic metabolic responses to cranberry polyphenol intake, particularly in populations with metabolic risk. In this randomized, double\u2010blind, placebo\u2010controlled pilot study, 45 overweight or obese adults received either cranberry juice providing 54.5\u2009mg\/day of total polyphenols or a placebo for 6\u2009weeks. Serum and urinary polyphenol metabolites were quantified via UPLC\u2013MS\/MS, and gut microbiota composition was assessed by 16S rRNA gene sequencing. Cranberry consumption significantly increased serum and urinary concentrations of catechol\u2010O\u2010sulfate and 4\u2010hydroxyhippuric acid, indicating enhanced polyphenol absorption and metabolism. While no overall shift was observed in gut microbial alpha diversity, subgroup analyses revealed increased richness in obese participants and females. Cranberry consumption was associated with taxonomic shifts, including increased abundance of\n                    <jats:italic>Anaerostipes<\/jats:italic>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Eubacterium hallii<\/jats:italic>\n                    <\/jats:styled-content>\n                    group, and\n                    <jats:italic>Eggerthella<\/jats:italic>\n                    . Notably,\n                    <jats:italic>Eggerthella<\/jats:italic>\n                    was not detected at baseline but was detected after 6\u2009weeks of cranberry consumption in 8 of 25 participants. Sparse partial least squares analysis showed a positive association between\n                    <jats:italic>Eggerthella<\/jats:italic>\n                    and serum 3\u2010(3\u2010hydroxyphenyl)propionic acid. These findings suggest a possible microbe\u2013metabolite relationship associated with cranberry intake, although the observed associations are correlative and require further functional validation.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71930","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:56:53Z","timestamp":1780117013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Low\u2010Dose Cranberry Polyphenols on Gut Microbiota and Circulating Polyphenol Metabolites in Overweight and Obese Individuals (A Randomized Double\u2010Blind Placebo\u2010Controlled Clinical Pilot Study)"],"prefix":"10.1002","volume":"14","author":[{"given":"Maria Jocelyn Chicas","family":"Castellon","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8724-4704","authenticated-orcid":false,"given":"Min Ji","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza Sirven","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Ariful","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Talcott","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-5073","authenticated-orcid":false,"given":"Seockmo","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-4044","authenticated-orcid":false,"given":"Susanne U.","family":"Mertens\u2010Talcott","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012583"},{"key":"e_1_2_11_4_1","unstructured":"Bolyen E. 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