{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:19:46Z","timestamp":1787606386219,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Depression and fatty liver disease exhibit a close bidirectional relationship, and depressed patients with fatty liver disease represent a clinically important subgroup. Although niacin intake has been shown to ameliorate fatty liver disease, its effects on depression remain inconsistent. This cross\u2010sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2017\u20132020 to investigate the association between niacin intake and depression in individuals with metabolic dysfunction\u2010associated fatty liver disease (MAFLD). Multivariate logistic regression was applied to evaluate the linear association, while smooth curve fitting and threshold effect analysis were performed to characterize nonlinear relationships. Subgroup analyses and interaction tests were conducted to assess the robustness of the findings. A nonlinear association was observed between niacin intake and depression in MAFLD patients. Threshold analysis identified an inflection point at approximately 10.24\u2009mg\/day, below which a significant inverse association was found (OR 0.80; 95% CI: 0.68\u20130.93), whereas no significant relationship was detected above this threshold. Subgroup analyses and interaction tests consistently confirmed the robustness of these findings. In conclusion, moderate niacin intake is associated with a lower risk of depression in patients with MAFLD, and the identified threshold of approximately 10.24\u2009mg\/day may serve as a reference value for future research.<\/jats:p>","DOI":"10.1002\/fsn3.71940","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:33:54Z","timestamp":1781872434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inverse Association Between Dietary Niacin Intake and Prevalence of Depressive Symptoms in Adults With Metabolic\u2010Associated Fatty Liver Disease: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiaoxian","family":"Yang","sequence":"first","affiliation":[{"name":"Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"},{"name":"First Clinical Medical College, Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Qin","sequence":"additional","affiliation":[{"name":"The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6567-2977","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2215\u20100366(16)30024\u20104"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/s2045796022000452"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.2224"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00181.2013"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.04.044"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70066"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P023614"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110583"},{"key":"e_1_2_14_11_1","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B(6), folate, Vitamin B(12), pantothenic Acid, Biotin, and Choline","author":"Institute of Medicine Standing Committee on the Scientific Evaluation of Dietary Reference, I., its Panel on Folate, O. 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