{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:11:19Z","timestamp":1789992679954,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chemotherapy\u2010induced skin and hair follicle damage, driven in part by miRNAs such as miR\u2010204 and miR\u2010375 that regulate apoptosis and autophagy after alkylating agent exposure, significantly impacts patient quality of life. While chrysin\u2014a common food\u2010derived flavonoid and nutritional bioactive with antioxidant and cytoprotective properties\u2014has shown potential to modulate miRNA activity, its role in melphalan\u2010induced injury and associated miRNA expression remains unclear. This study investigated the effects of melphalan on skin and hair follicle integrity in rats, focusing on miR\u2010204 and miR\u2010375 expression, and evaluated the protective potential of chrysin treatment. Forty\u2010eight male Wistar rats were divided into six groups receiving melphalan (1.5\u2009mg\/kg), chrysin (50 or 75\u2009mg\/kg), or their combination for 21\u2009days. Dorsal skin samples were analyzed using histological and morphometric assessments. Expression levels of apoptosis\u2010related genes, autophagy markers, and miR\u2010204\/miR\u2010375 were quantified by RT\u2010qPCR. Melphalan significantly reduced epidermal thickness and anagen\u2010phase hair follicles while increasing apoptosis markers (BAX, caspase\u20103) and suppressing autophagy\u2010related genes. It also markedly upregulated miR\u2010204 and miR\u2010375. Chrysin co\u2010administration, particularly at 75\u2009mg\/kg, correlates with restored epidermal thickness, improved hair follicle cycling, enhanced autophagy marker expression, suppressed apoptosis, and significantly downregulated miR\u2010204 and miR\u2010375. Chrysin reduces melphalan\u2010induced skin and hair follicle damage, possibly correlating with modulation of apoptosis and autophagy pathways and suppression of miR\u2010204 and miR\u2010375. These findings suggest chrysin as a promising nutraceutical candidate and supportive dietary strategy to help reduce chemotherapy\u2010associated dermatological side effects.<\/jats:p>","DOI":"10.1002\/fsn3.71946","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:27:21Z","timestamp":1779683241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of\n                    <scp>miR<\/scp>\n                    \u2010204 and\n                    <scp>miR<\/scp>\n                    \u2010375 Expression by Flavonoid Chrysin Treatment During Melphalan\u2010Induced Histopathological Damage in Adult Rat Skin and Hair Tissue"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9181-3477","authenticated-orcid":false,"given":"Maryam","family":"Moghimian","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Gonabad University of Medical Sciences  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0330-5574","authenticated-orcid":false,"given":"Zahra","family":"Parsamanesh","sequence":"additional","affiliation":[{"name":"Student Research Committee Gonabad University of Medical Sciences  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-9160","authenticated-orcid":false,"given":"Zahra","family":"Rajabzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee Gonabad University of Medical Sciences  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-0237","authenticated-orcid":false,"given":"Negar","family":"Shafaei\u2010Bajestani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Gonabad University of Medical Sciences  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-8834","authenticated-orcid":false,"given":"Malihe","family":"Soltani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine Gonabad University of Medical Sciences  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041212"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/der2.70028"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"Almeida V. D.Pires M.Silva et\u00a0al.2023.\u201cDermatological Side Effects of Cancer Treatment: Psychosocial Implications\u2014A Systematic Review of the Literature.\u201dPaper presented at the Healthcare.https:\/\/doi.org\/10.3390\/healthcare11192621.","DOI":"10.3390\/healthcare11192621"},{"issue":"2","key":"e_1_2_12_5_1","first-page":"64","article-title":"Cytotoxic and Genotoxic Effects of Melphalan in Normal and Cancerous Cells","volume":"3","author":"Alrifaie T. B. 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