{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:03:38Z","timestamp":1792281818174,"version":"4.4.0"},"reference-count":75,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200215"],"award-info":[{"award-number":["32200215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dendrobium chrysotoxum<\/jats:italic>\n                    Lindl., an important medicinal plant, contains polysaccharides (DCP) as its principal bioactive components. This review systematically outlines recent advances in the extraction, purification, structural characteristics, biological activities, and future prospects of DCP. For extraction, conventional hot water extraction followed by ethanol precipitation remains common but is limited by high energy consumption and prolonged duration. Advanced techniques, such as enzyme\u2010assisted extraction (yielding 8.41% under optimized conditions) and a combined ultrasonic\u2010hot water method (achieving 20.41% purity), significantly enhance efficiency. Purification generally involves deproteinization, removal of low\u2010molecular\u2010weight impurities, and fractionation via column chromatography to obtain homogeneous polysaccharide fractions. Structurally, DCP are heteropolysaccharides primarily consisting of glucose and mannose in varying molar ratios, with molecular weights ranging from 10\n                    <jats:sup>4<\/jats:sup>\n                    to 10\n                    <jats:sup>6<\/jats:sup>\n                    \u2009Da. Their backbone is mainly composed of (1\u21924)\u2010linked Manp and Glcp residues, featuring branching and partial acetylation. Biologically, DCP exhibit a broad spectrum of activities, including antioxidant and anti\u2010aging effects, immunomodulation, and organ protection. Additionally, DCP show hypoglycemic and antitumor potential, inhibiting proliferation of SPC\u2010A\u20101 and HeLa cells through apoptosis induction. Despite these findings, challenges remain including inefficient extraction and insufficient understanding of the structure\u2013activity relationships and molecular mechanisms underlying DCP's diverse biological activities. Future research should prioritize innovative extraction technologies, optimized purification, in\u2010depth mechanistic investigations, and the development of practical applications.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71951","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:56:09Z","timestamp":1780044969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Review of Extraction, Structural Properties, Biological Activities of\n                    <i>Dendrobium chrysotoxum<\/i>\n                    Polysaccharides"],"prefix":"10.1002","volume":"14","author":[{"given":"Xingshuai","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, School of Convergence Medicine Zhengzhou University  Zhengzhou China"},{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-9512","authenticated-orcid":false,"given":"Lihang","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, School of Convergence Medicine Zhengzhou University  Zhengzhou China"},{"name":"Henan Funiu Mountain Biological and Ecological Environment Observatory Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erad310"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2016.06.035"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.169"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130207"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.06.148"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.12048\/j.issn.1674\u2010229X.2022.05.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c02429"},{"issue":"10","key":"e_1_2_10_10_1","first-page":"709","article-title":"Studies on Polysaccharide, Alkaloids and Minerals From Dendrobium moniliforme (L.) 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