{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:47Z","timestamp":1790172167046,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Plant derived natural products and medicinal herbs have recently gain more attention as therapeutic agents to treat various ailments. The current study aims to explore the potential role of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. papaya<\/jats:italic>\n                    <\/jats:styled-content>\n                    's natural intervention in reducing the asbestos\u2010induced pulmonary damage. A total of 32 male albino rats were grouped into NC, PC, STD (Montelukast Sodium 10\u2009mg\/kg), and C.P (500\u2009mg\/kg) groups, having eight animals in each group. Experimental units from the PC were exposed to asbestos fibers in a glass chamber for 2\u20133\u2009h daily. Biological tissues for histopathology were preserved in formalin, lung tissue for qRT\u2010PCR was immersed in TRIzol, broncho\u2010alveolar lavage fluid (BALF) was collected for protein analysis, and serum was separated for oxidative biomarkers. Data was analyzed by the ANOVA and Tukey's test, and GraphPad Prism (v 8.0) was used for graphical representation. Results of the study revealed that after treatment, serum antioxidant markers were significantly enhanced in the C.P group\n                    <jats:italic>(p\u2009\u2264\u20090.05)<\/jats:italic>\n                    , whereas oxidative markers were reduced significantly in the C.P group\n                    <jats:italic>(p\u2009\u2264\u20090.05)<\/jats:italic>\n                    . Markers of protein analysis from BALF and wet\u2010to\u2010dry ratio increased in the PC group, but a significant decline was seen in the C.P group\n                    <jats:italic>(p\u2009\u2264\u20090.05)<\/jats:italic>\n                    . Results of qRT\u2010PCR showed upregulation of oxidative response pathway molecules and apoptotic markers in PC such as NRF1, DUOX, DUOXA1, DUOXA2, BAX, BID, CASP9, CYT\u2010C, and NFE\u20102\u2009L2. Parallel to this, an elevated response from antioxidant markers and calcium homeostasis regulators was seen in the C.P\u2010treated group. Microscopic insights revealed normal parenchyma of the lung and trachea in the NC group, which was worsened with thickened airways, fibrotic alveolar walls, and lodged fibers of asbestos seen in the tissue samples of the PC group. Treatment with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. papaya<\/jats:italic>\n                    <\/jats:styled-content>\n                    revealed a restored histopathological profile with better alveolar architecture and mitigated effects of asbestos fibers. The results of this study suggest that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. papaya<\/jats:italic>\n                    <\/jats:styled-content>\n                    exhibits strong antioxidant potential to mitigate oxidative stress caused by inorganic source.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71984","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:58:32Z","timestamp":1782727112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Potential of\n                    <scp>\n                      <i>Carica papaya<\/i>\n                    <\/scp>\n                    (L.) Extract on\n                    <scp>NRF2<\/scp>\n                    \/\n                    <scp>KEAP1<\/scp>\n                    and Apoptotic Pathways in Asbestos\u2010Induced Lung Toxicity"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2200-3572","authenticated-orcid":false,"given":"Usman","family":"Haider","sequence":"first","affiliation":[{"name":"Institute of Physiology and Pharmacology, Faculty of Veterinary Science University of Agriculture Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-0615","authenticated-orcid":false,"given":"Muhammad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology, Faculty of Veterinary Science University of Agriculture Faisalabad  Faisalabad Pakistan"},{"name":"Institute of Animal Science Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5125-0251","authenticated-orcid":false,"given":"Wania","family":"Nasir","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology, Faculty of Veterinary Science University of Agriculture Faisalabad  Faisalabad Pakistan"},{"name":"Department of Physiology The University of Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-1386","authenticated-orcid":false,"given":"Najeeb Ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology, Faculty of Veterinary Science University of Agriculture Faisalabad  Faisalabad Pakistan"},{"name":"Department of Rehabilitation Sciences The University of Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9470-1308","authenticated-orcid":false,"given":"Muhammad Saad","family":"Tariq","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology, Faculty of Veterinary Science University of Agriculture Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-8961","authenticated-orcid":false,"given":"Bilal","family":"Aslam","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology, Faculty of Veterinary Science University of Agriculture Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5407-3112","authenticated-orcid":false,"given":"Saif Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Public Health Rawalpindi Medical University  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-721X","authenticated-orcid":false,"given":"Junming","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory Animal Centre Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"73","article-title":"Harnessing Nature: The Role of Medicinal Plants in Alleviating Cisplatin Toxicity","volume":"45","author":"Abdelhiee E. 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