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CCP1A had a molecular weight of 8.161\u2009kDa and was primarily composed of glucose and galacturonic acid, with minor amounts of rhamnose, arabinose, galactose, xylose, and mannose. Spectroscopic analyses (FT\u2010IR and\n                    <jats:sup>1<\/jats:sup>\n                    H NMR) confirmed the coexistence of \u03b1\u2010 and \u03b2\u2010glycosidic linkages and a pyranose ring structure. The Congo red assay indicated a stable helical conformation, and transmission electron microscopy revealed dendritic, coiled aggregates. In a mouse model of type 2 diabetes induced by a high\u2010fat diet combined with low\u2010dose streptozotocin, oral administration of CCP1A (100, 200, and 300\u2009mg\/kg\/day for 4\u2009weeks) dose\u2010dependently reduced fasting blood glucose, improved glucose tolerance and lipid profiles (TG, TC, LDL\u2010C, and HDL\u2010C), and alleviated polydipsia, polyphagia, weight loss, as well as pancreatic pathological damage. Mechanistically, CCP1A suppressed intestinal \u03b1\u2010amylase and \u03b1\u2010glucosidase activities, promoted hepatic and muscle glycogen synthesis, upregulated the hepatic mRNA expression of GCK, GLUT2, PI3K, AKT, and Nrf2, downregulated PEPCK mRNA expression, increased serum levels of T\u2010SOD, GSH\u2010Px, CAT, and T\u2010AOC, and decreased MDA and GSP levels. These findings suggest that CCP1A exerts multi\u2010target hypoglycemic effects potentially involving inhibition of intestinal glucose absorption, modulation of insulin signaling\u2010related genes, promotion of glycogen synthesis, suppression of gluconeogenesis, and upregulation of Nrf2 mRNA. Hence, CCP1A represents a promising natural candidate for functional food development against type 2 diabetes.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71999","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:50:27Z","timestamp":1781095827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Characterization and Hypoglycemic Effects of a Purified Polysaccharide From\n                    <i>Cinnamomum cassia<\/i>"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5022-8316","authenticated-orcid":false,"given":"Liquan","family":"Zhou","sequence":"first","affiliation":[{"name":"Hunan Engineering and Technology Research Center for Health Products and Life Science, School of Pharmacy Hunan University of Chinese Medicine  Changsha China"},{"name":"Homologous Innovation Laboratory of Medicine and Food Hunan University of 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