{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:20:32Z","timestamp":1787606432589,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Allergic rhinitis (AR) is often exacerbated by antibiotic\u2010induced gut dysbiosis. This study investigated whether butyrylated starch (BS) could mitigate vancomycin (VAN)\u2010induced AR aggravation by restoring gut homeostasis. In a murine AR model (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095 per group), VAN administration significantly depleted the abundance of butyrate\u2010producing bacteria (e.g.,\n                    <jats:italic>Clostridia<\/jats:italic>\n                    and\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    ), suppressed colonic butyrate levels (1.08\u2009\u00b1\u20090.36 vs. 8.20\u2009\u00b1\u20090.78\u2009\u03bcg\/g in controls), and impaired intestinal barrier integrity, thereby worsening nasal symptoms (sneezing frequency: 4.40\u2009\u00b1\u20091.14 vs. 2.40\u2009\u00b1\u20090.55 in the AR group). Intervention with BS, a targeted butyrate precursor, effectively reversed these changes by increasing the abundance of butyrogenic taxa, increasing butyrate production (22.86\u2009\u00b1\u20093.27\u2009\u03bcg\/g), upregulating the expression of tight junction proteins (Occludin\u20101, ZO\u20101, and Claudin\u20103), and increasing the number of splenic regulatory T (Treg) cells. Our findings demonstrate that BS ameliorates antibiotic\u2010induced AR via coordinated restoration of the gut microbiota\u2010barrier\u2010immune axis, suggesting a novel dietary strategy for the management of allergic inflammation.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72000","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:25:47Z","timestamp":1780892747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Butyrylated Starch Attenuates Antibiotic\u2010Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuxi","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery The First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, National Regional Medical Center Binhai Campus of The First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Fujian Children's Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery The First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, National Regional Medical Center Binhai Campus of The First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery 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