{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:25Z","timestamp":1790172145143,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic gastritis is a prevalent global health concern, and there is growing interest in functional foods and nutraceuticals derived from traditional herbs as complementary approaches for gastrointestinal health management. The Fructus Aurantii Immaturus\u2010Bambusae Caulis in Taeniam (FAI\u2010BCT) herb pair exhibits health\u2010promoting effects against chronic gastritis, but the underlying molecular mechanisms, particularly of its bioactive constituents, remain unclear. We established an ultra\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight tandem mass spectrometry (UPLC\u2010Q\u2010TOF\u2010MS\/MS) method to identify the blood\u2010absorbed constituents and metabolites of FAI\u2010BCT in rat plasma. Combined with GEO database mining and targeted network pharmacology, molecular docking and molecular dynamics simulations were further performed to explore its anti\u2010gastritis mechanisms. 27 prototype components and 13 metabolites were identified or preliminarily characterized in plasma. Targeted network pharmacology identified 3\u2032,4\u2032,5,7\u2010tetramethoxyflavone, 5\u2032\u2010methoxynobiletin (M5), naringenin, hesperetin, p\u2010coumaric acid, ferulic acid, and nobiletin as key bioactive compounds. Core therapeutic targets included epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), B\u2010cell lymphoma 2 (BCL2), matrix metalloproteinase\u20109 (MMP9), protein kinase B\u2010\u03b1 (AKT1), and prostaglandin\u2010endoperoxide synthase 2 (PTGS2). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses highlighted the PI3K\u2010Akt signaling pathway as a key mechanism regulated by these compounds. Molecular docking verified strong binding affinities, and molecular dynamics simulations validated stable complex formations. This study elucidates the multi\u2010target mechanisms of FAI\u2010BCT in preventing and managing chronic gastritis, emphasizing the role of its highly bioavailable bioactive constituents. The findings provide robust evidence supporting FAI\u2010BCT's potential application in functional foods or nutraceuticals for chronic gastritis and underscore the importance of bioavailability\u2010focused research on traditional Chinese medicine (TCM) constituents.<\/jats:p>","DOI":"10.1002\/fsn3.72016","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:43:42Z","timestamp":1782920622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Bioactive Compounds and Multi\u2010Target Mechanisms of the Fructus Aurantii Immaturus\u2010Bambusae Caulis in Taeniam Herb Pair Against Chronic Gastritis: Integrating Identification of Absorbed Constituents, Targeted Network Pharmacology, and Computational Validation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5310-6200","authenticated-orcid":false,"given":"Yinghua","family":"Ma","sequence":"first","affiliation":[{"name":"Hebei Children's Hospital  Shijiazhuang Hebei People's Republic of China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease  Shijiazhuang Hebei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University  Shijiazhuang Hebei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Song","sequence":"additional","affiliation":[{"name":"Hebei Provincial Hospital of Traditional Chinese Medicine Office of Drug Clinical Trial Institution  Shijiazhuang Hebei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Qin","sequence":"additional","affiliation":[{"name":"Hebei Children's Hospital  Shijiazhuang Hebei People's Republic of China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease  Shijiazhuang Hebei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yile","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hebei Children's Hospital  Shijiazhuang Hebei People's Republic of China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease  Shijiazhuang Hebei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040803"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5013-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X13666190621125048"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155360"},{"key":"e_1_2_12_6_1","first-page":"6707","article-title":"MicroRNA\u2010936 Promotes Proliferation and Invasion of Gastric Cancer Cells by Down\u2010Regulating FGF2 Expression and Activating P13K\/Akt Signaling Pathway","volume":"24","author":"Chen Z. 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