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Nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells (NF\u2010\u03baB) is a master transcription factor that orchestrates inflammatory signaling, immune dysregulation, cellular proliferation, and survival pathways implicated in inflammation\u2010driven pathologies. Initiation and activation of other chronic inflammatory diseases can be linked to continued NF\u2010\u03baB activation, thus making it an attractive target for therapeutics. Dietary polyphenols that are found in fruits, vegetables, tea, coffee, and other foods have a broad therapeutic potential and have emerged as potent natural modulators of NF\u2010\u03baB signaling. Various studies have\u00a0highlighted the relevance of different classes of polyphenols. These classes, flavonoids, phenolic acids, and other polyphenolic compounds exert anti\u2010inflammatory and chemopreventive effects through multiple mechanisms, by suppressing NF\u2010\u03baB activation, inhibition of kinases, reduction of oxidative stress, and modulation of epigenetic and redox\u2010sensitive pathways. The present review provides insight into the mechanisms by which dietary polyphenols regulate NF\u2010\u03baB signaling and highlights their role in the prevention of inflammation\u2010driven NCDs.<\/jats:p>","DOI":"10.1002\/fsn3.72027","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:39:53Z","timestamp":1782985193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Polyphenols as Natural Modulators of\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signaling in Inflammation\u2010Driven Non\u2010Communicable Diseases: Focus on Cancer"],"prefix":"10.1002","volume":"14","author":[{"given":"Khuzin","family":"Dinislam","sequence":"first","affiliation":[{"name":"Department of General Chemistry Bashkir State Medical University  Ufa 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