{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:20:29Z","timestamp":1787606429880,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Laxatives are the primary treatment for functional constipation (FC), but they are not always effective and well\u2010tolerated. Dietary fiber can represent a valid alternative. This study aimed to determine whether combining dietary fibers from different origins could be a valuable strategy for FC. Thus, the efficacy of a fiber\u2010based formulation (MNS\u201036), composed of resistant dextrin from wheat starch (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Triticum aestivum<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.), pectin, and insoluble fibers from\n                    <jats:italic>Citrus<\/jats:italic>\n                    spp., and oat fibers (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Avena sativa<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.) was tested in a monocentric, double\u2010blind, randomized, placebo\u2010controlled clinical trial with 54 adults with FC. Participants received two sachets of MNS\u201036 or a placebo daily for 28\u2009days, with weekly visits and a follow\u2010up. Compared to the placebo group, bowel movements, used as the primary outcome of the study, increased significantly between baseline and week 4 (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20092.43\u2009\u00b1\u20090.23,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Similarly, Bristol Stool Form Scale scores significantly improved in the treatment group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), being normalized from week 2 onwards (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.008). In the treatment group, significant reductions were also observed in abdominal bloating (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20091.21\u2009\u00b1\u20090.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), abdominal distension (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20091.66\u2009\u00b1\u20090.18,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), heaviness (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20091.39\u2009\u00b1\u20090.21,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and flatulence (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20091.51\u2009\u00b1\u20090.26,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas abdominal pain did not differ significantly between groups. No adverse events were reported, and treatment adherence was high. These findings highlight the efficacy of combining soluble and insoluble fibers from different food origins in improving gut function, addressing both symptoms and tolerability, and underscore this strategy as a natural alternative approach to laxatives for managing FC.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72048","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:03:24Z","timestamp":1782457404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combination of Dietary Fibers From Different Food Origins as a Treatment for Adults With Functional Constipation: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"14","author":[{"given":"Alessandro","family":"Di Minno","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"},{"name":"CEINGE\u2010Biotecnologie Avanzate  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vittoria","family":"Morone","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Giuseppe","family":"Buccato","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza Francesca","family":"De Lellis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Ullah","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Management and Technology  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Cerqua","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Piccinocchi","sequence":"additional","affiliation":[{"name":"Level 1 Medical Director Anaesthesia and Resuscitation A. U. O. Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Riccioni","sequence":"additional","affiliation":[{"name":"R&amp;D Department Esserre Pharma Srl  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana\u00e8","family":"Larsen","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Baldi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"di Guglielmo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Piccinocchi","sequence":"additional","affiliation":[{"name":"Comegen S.c.S., Societ\u00e0 Cooperativa Sociale di Medici di Medicina Generale  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-6690","authenticated-orcid":false,"given":"Hesham R.","family":"El\u2010Seedi","sequence":"additional","affiliation":[{"name":"International Research Center for Food Nutrition and Safety Jiangsu University  Zhenjiang China"},{"name":"Chemistry Department, Faculty of Science Islamic University of Madinah  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-0074","authenticated-orcid":false,"given":"Roberto","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Applied Statistic Unit, Department of Earth and Environmental Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Daglia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli Federico II  Naples Italy"},{"name":"International Research Center for Food Nutrition and Safety Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514003675"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517212"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214611"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"Fitting Linear Mixed\u2010Effects Models Using lme4","volume":"67","author":"Bates D. 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