{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:22Z","timestamp":1790172202303,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515011102"],"award-info":[{"award-number":["2026A1515011102"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Resveratrol, a natural polyphenol, has been widely studied for its potential health benefits in obesity treatment, but its molecular mechanism remains elusive. This study investigates the molecular mechanisms by which resveratrol promotes the expression and secretion of Growth Differentiation Factor 15 (GDF15), a key regulator of energy homeostasis. Using both murine embryonic fibroblasts (MEFs) and human HepG2 cells, resveratrol dose\u2010dependently upregulates\n                    <jats:italic>Gdf15<\/jats:italic>\n                    mRNA and protein expression, as well as increases GDF15 secretion. Transcriptome analysis and subsequent validation experiments revealed that Activating Transcription Factor 3 (ATF3) mediates the effect of resveratrol on GDF15 expression. Additionally, resveratrol\u2010treated mice exhibited resistance to high\u2010fat diet\u2010induced obesity and increased plasma GDF15 levels. In\u00a0vivo studies in mice further confirmed that resveratrol treatment elevates GDF15 levels in liver, kidney, and colon tissues, and enhances downstream ERK signaling in the brain. Collectively, these findings suggest that GDF15 plays a critical role in mediating the anti\u2010obesity effects of resveratrol.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72052","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:51:13Z","timestamp":1782708673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resveratrol Attenuates Obesity by Inducing\n                    <scp>GDF15<\/scp>\n                    Expression via the p38\u2010\n                    <scp>ATF3<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Liufeng","family":"Mao","sequence":"first","affiliation":[{"name":"Central Laboratory The First Affiliated Hospital, Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Neurological Research Institute of Integrated Traditional Chinese and Western Medicine The First Affiliated Hospital, 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