{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:52Z","timestamp":1790172232472,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300927"],"award-info":[{"award-number":["82300927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes mellitus (T2DM) poses a major global health challenge due to its considerable disability and mortality rates. The complex etiology of T2DM involves hepatic steatosis and autophagy dysfunction. Previous research indicates that oleanolic acid (OA) ameliorates T2DM, with signal transducer and activator of transcription 3 (STAT3) serving as a crucial regulator in numerous cellular processes. Therefore, this study aims to explore whether the therapeutic effects of OA are associated with STAT3 activation and its potential role in hepatic lipid metabolism and autophagy in T2DM. T2DM was induced in mice by feeding a high\u2010fat diet followed by multiple low\u2010dose streptozotocin injections. OA notably lowered blood glucose and lipid levels, along with improvements in glucose tolerance and insulin sensitivity. Additionally, OA alleviated liver injury and steatosis. In T2DM mice, OA reduced hepatic protein and gene expression associated with fatty acid uptake\/synthesis while enhancing those linked to fatty acid \u03b2\u2010oxidation. Moreover, OA modulated autophagy\u2010related proteins, as evidenced by increased p62 levels and decreased LC3\u2010II and Beclin\u20101 levels. Molecular docking analysis predicted a potential interaction between OA and STAT3, and Western blot showed increased STAT3 phosphorylation at Y705 after OA treatment\n                    <jats:italic>.<\/jats:italic>\n                    In\u00a0vitro, STAT3 inhibition blunted the ability of OA to restore the expression profiles of autophagy and lipid metabolism in insulin\u2010resistant liver cells. Collectively, OA may ameliorate T2DM via concomitant STAT3 phosphorylation to modulate hepatic lipid metabolism and autophagy. This study offers novel insights into the mechanisms by which OA treats T2DM, presenting fresh perspectives for T2DM clinical management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72063","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:36:08Z","timestamp":1784176568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oleanolic Acid Ameliorates Hepatic Lipid Metabolism and Autophagy in Type 2 Diabetic Mice via the\n                    <scp>STAT3<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Zirui","family":"Ji","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjin","family":"Pu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqing","family":"Feng","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Liao","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfen","family":"Lin","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-589X","authenticated-orcid":false,"given":"Weixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Research Institute Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases  Guangzhou Guangdong China"},{"name":"Key Laboratory of Glucolipid Metabolic Diseases Ministry of Education  Guangzhou Guangdong China"},{"name":"Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010015\u20101154\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115789"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010020\u201001621\u2010y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0169"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)30058\u20102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.08.029"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.03.011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102002\u201030102"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116864"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.009"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2603"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201054743\u20105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.27719"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.162"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14050598"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.05.010"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm980"},{"key":"e_1_2_11_19_1","volume-title":"IDF Diabetes Atlas (11th ed.)","author":"International Diabetes Federation (IDF)","year":"2025"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010018\u20102860\u20106"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199\u2010020\u201000326\u2010z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3158"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16256"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061411"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020300"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765\u2010020\u201000547\u20105"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2020.106"},{"issue":"3","key":"e_1_2_11_28_1","first-page":"351","article-title":"Re\u2010Evaluation of Fatty Acid Metabolism\u2010Related Gene Expression in Nonalcoholic Fatty Liver Disease","volume":"20","author":"Kohjima M.","year":"2007","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2689"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105637"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07\u20100907"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.7.152"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.888719"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.272"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1912270"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26189161"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.10.074"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010009\u20101347\u20102"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24517"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2017.32.1.6"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154661"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110676"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311557110"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.06.205"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20103868\u20109"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010023\u201001424\u20109"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166666"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010014\u20103185\u20100"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101326.2011.01488.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201001995\u20104"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2010.10.001"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106646"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3240713"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/973287"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.06.014"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010024\u201002959\u20102"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015\u20101866"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.880359"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02257"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.032"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112872"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200533"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030643"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.72063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:19:49Z","timestamp":1790169589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.72063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/fsn3.72063"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.72063","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72063"}}