{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:55:19Z","timestamp":1790618119736,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease associated with oxidative stress and inflammation. Natural products may offer protective effects, though their mechanisms remain unclear. Hawthorn fruit (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Crataegus monogyna<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) is known for its antioxidant and anti\u2010inflammatory properties, providing a rationale to explore its potential against UC ObjectiveTo evaluate the protective effects and mechanisms of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Crataegus monogyna<\/jats:italic>\n                    <\/jats:styled-content>\n                    fruit extract (CMFE) in acetic acid\u2010induced UC in rats. MethodsSix groups of Wistar rats were used: control, acetic acid (AA), AA + CMFE (100, 200, 400\u2009mg\/kg, p.o.), and AA + sulfasalazine (100\u2009mg\/kg, p.o.). Treatments lasted 10\u2009days, followed by AA rectal infusion (300\u2009mg\/kg). Colonic damage was assessed macroscopically and histologically. Oxidative stress markers (MDA, thiols, SOD, CAT, GPx) were measured in colon homogenates, while CRP, ALP, iron, and calcium levels were determined in plasma. ResultsCMFE pretreatment significantly reduced macroscopic and microscopic damage, protecting the colonic mucosa from AA\u2010induced lesions. AA increased MDA and decreased SH\u2010group as well as antioxidant enzyme activities, whereas CMFE restored these parameters. CMFE also normalized CRP, ALP, iron, and calcium levels, counteracting AA\u2010induced inflammatory and metabolic disturbances. ConclusionCMFE shows strong protective effects against AA\u2010induced colitis by modulating oxidative stress and inflammation. These findings support its potential use in green medicine as a natural therapeutic agent for inflammatory bowel diseases.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72074","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:39:36Z","timestamp":1783312776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preventive Effects of\n                    <scp>\n                      <i>Crataegus monogyna<\/i>\n                    <\/scp>\n                    Fruit Extract on Oxidative Damage and Inflammatory Response in a Rat Model of Acetic Acid\u2010Induced Ulcerative Colitis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8475-7854","authenticated-orcid":false,"given":"Soumaya","family":"Wahabi","sequence":"first","affiliation":[{"name":"Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5650-6890","authenticated-orcid":false,"given":"Dhekra","family":"Grami","sequence":"additional","affiliation":[{"name":"Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaoula","family":"Gharbi","sequence":"additional","affiliation":[{"name":"Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slimen","family":"Selmi","sequence":"additional","affiliation":[{"name":"Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-1401","authenticated-orcid":false,"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04710"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000503300207"},{"key":"e_1_2_14_5_1","first-page":"28","article-title":"Role of Phytochemicals in Health and Nutrition","volume":"3","author":"Almodaifer S.","year":"2017","journal-title":"BAOJ Nutrition"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.114919"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.173753"},{"issue":"1","key":"e_1_2_14_8_1","first-page":"13","article-title":"Assessment of Anti\u2010Ulcer Efficacy of Stem Bark Extract of Nauclea Latifolia (African Peach) in Rats","volume":"4","author":"Balogun M. 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