{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:12Z","timestamp":1790172132297,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Elsholtzia ciliata<\/jats:italic>\n                    <\/jats:styled-content>\n                    is a potential source of potent antioxidant phenolic compounds. This study investigated the ultrasound\u2010assisted extraction (UAE) of phenolic compounds (TPC) and chlorogenic acid (CGA) from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. ciliata<\/jats:italic>\n                    <\/jats:styled-content>\n                    (ELC) leaf extract. The study also evaluated the antioxidant efficacy of the extract during the preservation of 8F fat\u2010containing gummy candies. Using the response surface method (RSM), the optimal extraction temperature, time, and sonication time were predicted to be 77\u00b0C, 67\u2009min, and 3.6\u2009min, respectively. At the same time, ethanol concentration (60%), pH (5.5), and material\u2010to\u2010solvent ratio (1:18) were fixed based on preliminary selection. Under these conditions, TPC, CGA, and antioxidant activity reached 28.45\u2009\u00b1\u20090.5\u2009mg gallic acid equivalents (GAE)\/g dry weight (DW), 6.07\u2009\u00b1\u20090.18\u2009mg\/g DW, and 304.72\u2009\u00b1\u20090.83\u2009\u03bcmol Trolox equivalents (TE)\/g DW, respectively. Scanning electron microscopy (SEM) images showed that UAE conditions were favorable for the release of phenolic compounds. When incorporated into gummy candies, lipid oxidation was monitored over 49\u2009days by measuring peroxide (PV) and thiobarbituric acid reactive substances (TBARS) values and compared to butylhydroxytoluene (BHT) and vitamin E. These results support the use of the ELC extract as a natural antioxidant to stabilize fatty foods.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72080","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:56:22Z","timestamp":1783364182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recovery of Phenolic Compounds From\n                    <scp>\n                      <i>Elsholtzia ciliata<\/i>\n                    <\/scp>\n                    Leaves by Ultrasound\u2010Assisted Extraction and Their Antioxidant Application in Food"],"prefix":"10.1002","volume":"14","author":[{"given":"Nguyen Phuong Vi","family":"Truong","sequence":"first","affiliation":[{"name":"Department of Food Technology, Faculty of Chemical Engineering Ho Chi Minh City University of Technology (HCMUT), VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Department of Food Technology Thu Dau Mot University  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Diem Ai","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Chemical Engineering Ho Chi Minh City University of Technology (HCMUT), VNU\u2010HCM  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-9871","authenticated-orcid":false,"given":"Huu Hieu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Chemical Engineering Ho Chi Minh City University of Technology (HCMUT), VNU\u2010HCM  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-2005","authenticated-orcid":false,"given":"Thi Anh Dao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Chemical Engineering Ho Chi Minh City University of Technology (HCMUT), VNU\u2010HCM  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.19070\/2326\u20103350\u20101400028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2014.10.023"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12042107"},{"issue":"11","key":"e_1_2_11_6_1","first-page":"234","article-title":"Characterization and Determination of Chlorogenic Acids (CGA) in Coffee Beans by UV\u2010Vis Spectroscopy","volume":"3","author":"Belay A.","year":"2009","journal-title":"African Journal of Pure and Applied Chemistry"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations8070094"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jarmap.2021.100330"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0023\u20106438(95)80008\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/82.3.759"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2016.06.035"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00690"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26133783"},{"key":"e_1_2_11_15_1","volume-title":"Design of Experiments: Principles and Applications","author":"Eriksson L.","year":"2008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990489j"},{"key":"e_1_2_11_17_1","first-page":"131918","volume-title":"Food Chemistry","author":"Gil\u2010Mart\u00edn E.","year":"2022"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10144774"},{"key":"e_1_2_11_19_1","unstructured":"Hames B. 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