{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:33Z","timestamp":1790172153521,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigate the crude ethanolic extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Oenothera laciniata<\/jats:italic>\n                    <\/jats:styled-content>\n                    (EOL) and its solvent fractions n\u2010hexane (NHOL), dichloromethane (DCMOL), ethyl acetate (EAOL), and aqueous (AQOL) for their phytochemical composition and antidiabetic potential through in\u00a0vitro and in\u00a0vivo analyses. GC\u2013MS profiling revealed that the DCMOL fraction contained 8 compounds while the EAOL and NHOL fractions contained 19 and 20 compounds, respectively. Antioxidant evaluation using DPPH, ABTS, and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    assays demonstrated that DCMOL exhibited the strongest free radical scavenging activity with the lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    values across all assays. Enzyme inhibition studies demonstrated that DCMOL, EAOL, and NHOL possessed significant \u03b1\u2010glucosidase and \u03b1\u2010amylase inhibitory activities, comparable to acarbose. In\u00a0vivo studies confirmed that DCMOL significantly reduced blood glucose levels and improved glucose tolerance without inducing hepatotoxic or nephrotoxic effects. Histopathological analysis revealed partial restoration of pancreatic, hepatic, and renal architecture, particularly in the DCMOL and EAOL treated groups.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>O. laciniata<\/jats:italic>\n                    <\/jats:styled-content>\n                    , especially its DCMOL and EAOL fractions, exhibited strong antioxidant, enzyme inhibitory and antidiabetic activities, highlighting its potential as a natural multi\u2010target therapeutic candidate for diabetes management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72095","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:37:59Z","timestamp":1783939079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Therapeutic Potential of\n                    <i>Oenothera laciniata<\/i>\n                    : Antioxidant, Anti\u2010Hyperglycemic and Histopathological Activities Using In\u00a0Vitro and In\u00a0Vivo Approaches"],"prefix":"10.1002","volume":"14","author":[{"given":"Dur\u2010E\u2010Najaf","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Swabi  Swabi KP Pakistan"},{"name":"Department of Pharmacy Bacha Khan University  Charsadda KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Muhammad Mukarram","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Swabi  Swabi KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muska Mahabat","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Swabi  Swabi KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehman","family":"Zafar","sequence":"additional","affiliation":[{"name":"Akson College of Pharmacy Mirpur University of Science and Technology  Mirpur AJ &amp; Kashmir Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-6510","authenticated-orcid":false,"given":"Muhammad Saeed","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bacha Khan University  Charsadda KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ibrar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Swabi  Swabi KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-5491","authenticated-orcid":false,"given":"Abdur","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Swabi  Swabi Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-8076","authenticated-orcid":false,"given":"Yahya S.","family":"Al\u2010Awthan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-6674","authenticated-orcid":false,"given":"Omar S.","family":"Bahattab","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3161-3136","authenticated-orcid":false,"given":"Rakibur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"85","article-title":"Mechanisms of Actions of Some Bioactive Anti\u2010Diabetic Principles From Phytochemicals of Medicinal Plants: A Review","volume":"9","author":"Aba P. 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