{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:34Z","timestamp":1790172214873,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24Y12801100"],"award-info":[{"award-number":["24Y12801100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Offshore seafarers face a unique \u201cmetabolically obesogenic\u201d environment, predisposing them to an elevated risk of central obesity and metabolic disorders, even at a young age, creating a critical need for feasible, on\u2010board nutritional interventions. This study aimed to evaluate the effects of Chitooligosaccharides\u2010combination fortified noodles on body composition in young male seafarers and to elucidate the underlying systemic metabolic mechanisms. A self\u2010controlled trial was conducted with 73 participants, who underwent a 4\u2010week placebo phase followed, after a washout, by a 4\u2010week intervention phase consuming functional noodles every other day. Clinical assessments included body weight, waist circumference, body composition indices, and serum lipid profiles, and untargeted metabolomics was performed on a subset of 38 participants. Compared with the placebo phase, oligosaccharide intervention significantly reduced waist circumference (WC), visceral fat area (VFA), serum leptin and LDL\u2010cholesterol (LDL\u2010C) levels, and increased skeletal muscle mass index, with no significant change in body weight. Linear mixed models confirmed significant net reductions in VFA (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u221218.36\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , 95% CI: \u221231.56 to \u22125.16;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), WC (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22127.51\u2009cm, 95% CI: \u221210.78 to \u22124.23;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and LDL\u2010C (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.33\u2009mmol\/L, 95% CI: \u22120.55 to \u22120.11;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.005) following the intervention. Untargeted metabolomics revealed profound perturbations in the serum metabolome, with glycerophospholipid and thiamine metabolism identified as the most significantly dysregulated pathways. Key metabolites in these pathways exhibited marked alterations: phosphatidylethanolamine PE(18:3\/12:0) and thiamine triphosphate (ThTP) were upregulated, while lysophosphatidylserine LysoPS(19:0\/0:0) was downregulated. These metabolic changes were strongly associated with clinical improvements, with elevations in PE(18:3\/12:0) and ThTP being inversely correlated with reductions in VFA, WC, and LDL\u2010C, and the decrease in LysoPS(19:0\/0:0) positively correlated with these same clinical changes. Subgroup analysis indicated that seafarers with elevated central adiposity at baseline had a deficient metabolic state with lower levels of PE(18:3\/12:0) and ThTP, and these participants derived greater corrective benefits in these metabolites and VFA reduction from the intervention; notably, baseline LysoPS(19:0\/0:0) levels were comparable between subgroups, but its downregulation in response to the intervention was more pronounced in non\u2010centrally obese individuals. A four\u2010week dietary intervention with Chitooligosaccharides\u2010combination fortified noodles effectively reduced visceral adiposity and improved body composition in young seafarers, with benefits associated with targeted remodeling of glycerophospholipid and thiamine metabolism. The greater corrective response in individuals with pre\u2010existing central obesity highlights the potential of this strategy for precision nutrition in high\u2010risk occupational groups.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72101","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:26:51Z","timestamp":1784964411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Chitooligosaccharides\u2010Combination Fortified Noodles Intervention on Visceral Adiposity and Serum Metabolites in a High\u2010Risk Occupational Cohort of Young Seafarers"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhongbo","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Nutrition, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanYing","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-6017","authenticated-orcid":false,"given":"Xiao guo","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1622-8042","authenticated-orcid":false,"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01807-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.05.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-023-04826-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-04206-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5603\/IMH.2016.0013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13154-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1014778"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00839-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11111645"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40643-022-00500-y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.618037"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020150050000009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/325464"},{"issue":"1","key":"e_1_2_11_15_1","first-page":"130","article-title":"Beriberi Outbreak Among Commercial Fishermen, Thailand 2005","volume":"38","author":"Doung\u2010ngern P.","year":"2007","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.054379"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac232"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100777"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517596"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5603\/IMH.2014.0018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5603\/IMH.2016.0025"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104333"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01899-22"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade7864"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1718169"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04189-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13542"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.71369"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jth.2024.101816"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.048025"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-014-1452-1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30084-1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-021-00329-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.115153"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.05.055"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-6377-6"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.5603\/IMH.2013.0003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48009-6"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20054497"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj-2022-141972"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42473-2"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109208"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1207394"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1031502"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18010069"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c09397"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13132157"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxac037"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c06354"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145595"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3899"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-018-0190-0"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.72101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:19:10Z","timestamp":1790169550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.72101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/fsn3.72101"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.72101","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72101"}}