{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:31Z","timestamp":1790172211837,"version":"4.1.0"},"reference-count":219,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neuronal damage and cerebral impairment are defining characteristics of Alzheimer's disease (AD), a progressive neurodegenerative disorder associated with amyloid\u2010\u03b2 aggregation, oxidative stress, and neuroinflammation. Current treatments mainly provide symptomatic relief and do not effectively prevent disease progression, highlighting the need for novel disease\u2010modifying strategies. Marine microorganisms produce amphiphilic substances called biosurfactants that exhibit diverse biological properties, including anti\u2010inflammatory, antioxidant, and neuroprotective activities. Due to their amphiphilic nature, biosurfactants may interact with cellular membranes and modulate crucial pathological processes in AD, including inhibiting amyloid\u2010\u03b2 fibrillation, reducing oxidative stress, suppressing neuroinflammation via pathways such as NF\u2010\u03baB signaling, and enhancing drug delivery across the blood\u2013brain barrier. Notably, various biosurfactant classes, such as lipopeptides, exhibit significant neuroprotective potential. This review explores the structural diversity and biological functions of marine biosurfactants, their potential as therapeutic candidates for managing AD, and the pathophysiology of AD. Overall, marine biosurfactants represent promising and sustainable therapeutic options for AD; however, extensive experimental and clinical research is necessary to confirm their effectiveness.<\/jats:p>","DOI":"10.1002\/fsn3.72106","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:27:53Z","timestamp":1784532473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Implications of Marine Biosurfactants and Their Therapeutic Potential Against Alzheimer's Disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Zainab","family":"Irfan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan (Deemed to Be University)  Bhubaneswar Odisha India"},{"name":"Department of Pharmaceutical Technology Brainware University  Kolkata West Bengal 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