{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:04:02Z","timestamp":1793016242861,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic inflammation underlies the initiation of steatohepatitis in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD). Diet\u2010induced inflammation has been highlighted as a contributor to the development of hepatic steatosis. However, its involvement in steatohepatitis risk remains unstudied. This longitudinal analysis included 1130 individuals with MASLD from the Ravansar Non\u2010Communicable Disease cohort, who were followed from 2015 to 2023. At baseline, MASLD was assessed using the hepatic steatosis index (HSI), a validated non\u2010invasive scoring system. Usual dietary intakes were collected using a validated food frequency questionnaire (FFQ). The diet's potential to modulate inflammation\u2010related biomarkers was assessed using the dietary inflammatory index (DII). The acNASH index was employed as a more accurate and effective assessment for steatohepatitis risk in individuals with MASLD. After controlling for confounders, DII scores were significantly associated with changes in weight, ALT, and acNASH scores. Each one\u2010point increment in the DII score was independently associated with a 0.45% (95% CI: 0.10\u20130.80;\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value: 0.012) increase in weight, 2.27% (95% CI: 0.19\u20134.35;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032) increase in ALT, and 1.96% (95% CI: 0.36\u20133.55;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) increase in acNASH scores. For each 1% weight gain, the acNASH score increased by 0.63% (95% CI: 0.37\u20130.88;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Weight changes mediated 10.1% of the total relationship between the DII scores and percentage changes in acNASH score (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The association between DII scores and acNASH scores remained statistically significant across all strata of gender, socioeconomic status, and physical activity levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). This study demonstrated a direct association between diet\u2010induced inflammation and increased steatohepatitis risk in patients with MASLD. These findings highlight the importance of promoting anti\u2010inflammatory dietary patterns and weight management as feasible strategies to reduce the risk of steatohepatitis in patients with MASLD in clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72109","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:47:52Z","timestamp":1783918072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Pro\u2010Inflammatory Diets With Increased Risk of Metabolic Dysfunction\u2010Associated Steatohepatitis: Evidence From a Prospective Cohort Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Saideh","family":"Fathi","sequence":"first","affiliation":[{"name":"Nutritional Sciences Department, School of Nutrition Sciences and Food Technology Kermanshah University of Medical Sciences  Kermanshah 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and Food Technology Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Najafi","sequence":"additional","affiliation":[{"name":"Research Center for Environmental Determinants of Health, Health Institute Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Miryan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Sedighi","sequence":"additional","affiliation":[{"name":"Nutritional Sciences Department, School of Nutrition Sciences and Food Technology Kermanshah University of Medical Sciences  Kermanshah 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