{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:25Z","timestamp":1790172085407,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bone disorders are common in kidney transplant (KT) recipients. This research explores the impact of synbiotic supplementation on markers related to bone turnover in these patients. In a randomized controlled trial, 46 KT recipients were allocated at random to either a synbiotic group or a placebo group. Those in the synbiotic group received two capsules daily for a duration of 12\u2009weeks, while the placebo group was given an equivalent placebo. The study measured several bone resorption markers, including C\u2010telopeptide and receptor activator of nuclear factor kappa B ligand (RANKL), as well as serum levels of the bone formation marker osteocalcin and the bone resorption inhibitor osteoprotegerin. The findings revealed that serum levels of C\u2010telopeptide were significantly lower in the synbiotic group compared to the placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). There was a significant increase in osteocalcin levels within the synbiotic group compared to the placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041). Serum concentrations of RANKL and osteoprotegerin decreased significantly in both the synbiotic and placebo groups compared to baseline. However, the change in serum concentrations of RANKL and osteoprotegerin did not show a significant difference between the two groups. Throughout the study period, no significant changes were observed in serum iPTH, calcium, phosphorus, or 25\u2010hydroxycholecalciferol levels within each group. In conclusion, synbiotic supplementation decreases serum C\u2010telopeptide, a marker of bone resorption, and increases serum osteocalcin, a marker of bone formation, in KT recipients.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72117","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:57:48Z","timestamp":1784091468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Synbiotic Supplementation on Bone Turnover Markers in Kidney Transplant Recipients: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-5400","authenticated-orcid":false,"given":"Zeinab","family":"Karimi","sequence":"first","affiliation":[{"name":"Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-7772","authenticated-orcid":false,"given":"Hadi","family":"Tabibi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition &amp; Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Nafar","sequence":"additional","affiliation":[{"name":"Chronic Kidney Disease Research Center, Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Samavat","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Firouzan","sequence":"additional","affiliation":[{"name":"Chronic Kidney Disease Research Center, Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010015\u20108522\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u20102730000003384"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e05925"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114523002362"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12101000"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15050301"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.BAD\u20100015\u20102016"},{"key":"e_1_2_11_9_1","first-page":"1","volume-title":"Comprehensive Guide to Transplant Nutrition","author":"DiCeco S. 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