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If left untreated, fibrosis may lead to cirrhosis or hepatocellular carcinoma.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Phyllanthus emblica<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Panax ginseng<\/jats:italic>\n                    <\/jats:styled-content>\n                    C.A. Meyer possess hepatoprotective, antioxidant, and immunomodulatory properties. The aim of this study is to evaluate the individual and combined effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. emblica<\/jats:italic>\n                    <\/jats:styled-content>\n                    fruit and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. ginseng<\/jats:italic>\n                    <\/jats:styled-content>\n                    root powders against APAP induced liver fibrosis in a rat model. A 38\u2010day study trial was conducted using 20 male Wistar rats, which were divided into five groups, each group containing four rats. Hepatotoxic doses of APAP were administered for 10\u2009days to induce early\u2010stage liver fibrosis in rats. A negative control group (G0) on normal diet without liver fibrosis, a positive control group with liver fibrosis on a normal diet (G1), and treatment groups (G2, G3, G4) receiving varying doses of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. emblica<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. ginseng<\/jats:italic>\n                    <\/jats:styled-content>\n                    were evaluated for liver function tests (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, albumin), oxidative stress biomarkers (glutathione), hematological indices and histopathological analysis. Results demonstrated that combination treatment G4 significantly improved liver function biomarkers, and normalized hematological parameters. However,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. emblica<\/jats:italic>\n                    <\/jats:styled-content>\n                    restored glutathione levels most effectively among all treatments. Histological examination revealed a marked reduction in necrosis and fibrosis. This study concluded that combined activity of bioactive components of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. emblica<\/jats:italic>\n                    <\/jats:styled-content>\n                    (vitamin C, ellagic acid, gallic acid) and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. ginseng<\/jats:italic>\n                    <\/jats:styled-content>\n                    (ginsenosides) significantly attenuated APAP\u2010induced hepatic damage and fibrosis, underscoring their potential role as complementary therapeutic options for drug\u2010induced liver disorders and halting fibrotic advancement.\n                  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