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Although\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    (AKK) has emerged as a promising next\u2010generation probiotic for metabolic health, its synergistic potential with natural anti\u2010obesity compounds remains largely unexplored. Here, we evaluated the combined administration of pasteurized\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    (AKM Lab\u201001) and\n                    <jats:italic>Garcinia cambogia<\/jats:italic>\n                    extract (GCE) in a mouse model of high\u2010fat diet\u2010induced obesity. The combination treatment significantly ameliorated obesity\u2010related phenotypes, including reduced body weight, decreased fat mass, improved serum metabolic parameters, and attenuated adipose tissue inflammation. Adipose tissue transcriptomic profiling revealed enhanced lipid catabolism and downregulation of pro\u2010inflammatory pathways. Metagenomic sequencing showed marked gut microbiota remodeling, characterized by increased abundance of\n                    <jats:italic>Lactococcus<\/jats:italic>\n                    and decreased levels of\n                    <jats:italic>Clostridium<\/jats:italic>\n                    and\n                    <jats:italic>Eisenbergiella<\/jats:italic>\n                    . Integrated correlation analysis linked these microbial shifts to transcriptional reprogramming in adipose tissue. Using a 3\u2009T3\u2010L1 adipocyte model, we further confirmed that\n                    <jats:italic>Lactococcus<\/jats:italic>\n                    plays a potential role in regulating lipid metabolism and inflammation. Collectively, these findings strongly suggest that the AKM Lab\u201001 and GCE combination may exert synergistic anti\u2010obesity effects via a gut microbiota\u2013host metabolic axis, supporting its potential as a novel synbiotic strategy for obesity management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72140","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:13:37Z","timestamp":1785302017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Anti\u2010Obesity Effect of\n                    <i>Akkermansia muciniphila<\/i>\n                    AKM Lab\u201001 and\n                    <i>Garcinia cambogia<\/i>\n                    Extract via Gut Microbiota Remodeling in Diet\u2010Induced Obese Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Baojia","family":"Huang","sequence":"first","affiliation":[{"name":"Moon (Guangzhou) Biotech Co. Ltd.  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1585-2123","authenticated-orcid":false,"given":"Zhipeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Moon (Guangzhou) Biotech Co. Ltd.  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Xue","sequence":"additional","affiliation":[{"name":"Moon (Guangzhou) Biotech Co. Ltd.  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilun","family":"Pu","sequence":"additional","affiliation":[{"name":"Moon (Guangzhou) Biotech Co. Ltd.  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