{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:11Z","timestamp":1791003191821,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the chemical composition, safety profile, and pharmacological activities of a decocted extract from the aerial parts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mentha aquatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MA\u2010DE). High\u2010performance liquid chromatography with diode\u2010array detection (HPLC\u2010DAD) identified several phenolic constituents, mainly hydroxycinnamic and hydroxybenzoic acids. Safety was evaluated through acute and subacute toxicity studies in albino mice. Acute toxicity testing involved oral and intraperitoneal administration of MA\u2010DE at doses up to 8\u2009g\/kg body weight (BW). Oral administration produced no mortality or observable toxic effects, whereas intraperitoneal administration induced dose\u2010dependent toxicity, with an LD\n                    <jats:sub>50<\/jats:sub>\n                    of 5.975\u2009g\/kg BW; the NOAEL and LOAEL were determined as 0.5 and 1\u2009g\/kg BW, respectively. In the subacute study, mice received daily oral doses of 0.1, 0.5, or 1\u2009g\/kg BW for 28\u2009days, with no significant changes observed in hematological, biochemical, or histopathological parameters compared with controls. The anti\u2010inflammatory activity of MA\u2010DE was assessed using the carrageenan\u2010induced paw edema model in Wistar rats, while analgesic activity was evaluated using the writhing test. MA\u2010DE exhibited significant, dose\u2010dependent anti\u2010inflammatory and analgesic effects at 200 and 400\u2009mg\/kg BW. Overall, MA\u2010DE appears safe when administered orally and demonstrates promising pharmacological properties, supporting its traditional use and potential phytotherapeutic application.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72142","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:54:58Z","timestamp":1785498898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Phytochemical and Pharmacological Investigation of\n                    <i>Mentha aquatica<\/i>\n                    L.: Anti\u2010Inflammatory, Analgesic, and Safety Evidence From In\u00a0Vivo Studies"],"prefix":"10.1002","volume":"14","author":[{"given":"Meryem","family":"Tourabi","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology, Conservation and Valorization of Bioresources, Faculty of Sciences Sidi Mohamed Ben Abdellah University  Fez 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