{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:18Z","timestamp":1791003198775,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rabbit meat is increasingly valued for its high nutritional quality, driving growing interest in enhancing its production through phytobiotics like plant\u2010based flavonoid blend (PFB). So, this study looked at how a PFB at different doses influences the performance, digestibility, gut microbiota, blood biomarkers, liver health, and meat quality of growing rabbits. Sixty rabbits (body weight 552.63\u2009\u00b1\u200913.44\u2009g) were assigned at random to five dietary groups, having twelve replicates per group. The rabbits were fed a basal diet as a total mixed ration having 17.02% crude protein and 11.60\u2009MJ metabolizable energy\/kg dry matter (DM), supplemented with PFB (g\/kg diet) at 0.0 (control), 0.20, 0.40, 0.60, and 0.80. Following a 2\u2009weeks adjustment period, the feeding trial was conducted for 5\u2009weeks. When the trial was over, rabbits were sacrificed to collect digesta, blood, and meat samples for further analysis. Supplementation with PFB at 0.60\u2009g\/kg diet (range: 0.50\u20130.70\u2009g\/kg) showed a better final body weight (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), weight gain (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and feed conversion ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while significantly improving DM, nitrogen\u2010free extract (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and ether extract (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) digestibility. Besides, supplementation with PFB presented a linear reduction in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), accompanied by linear improvement in\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    spp. (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and serum high density lipoprotein\u2010cholesterol (HDL\u2010C;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Broken\u2010line analysis indicated optimal PFB supplementation levels of 0.60, 0.47, and 0.60\u2009g\/kg diet for\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">E.\u2009coli<\/jats:styled-content>\n                      , Lactobacillus\n                    <\/jats:italic>\n                    spp., and HDL\u2010C, respectively. However, feed intake, serum triglycerides, other cholesterols, total protein, albumin, globulin, and uric acid remained unchanged across the groups. Furthermore, supplementation with PFB with an estimated breakpoint of 0.55\u2009g PFB\/kg of diet effectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.02) reduced serum liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) indicating better liver health. In addition, PFB supplementation linearly reduced meat ether extract content and improved meat redness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with optimal responses at 0.58 and 0.60\u2009g\/kg diet, respectively, while having no impacts on meat protein, ash, lightness, or yellowness. Therefore, dietary inclusion of PFB at 0.55\u2009g\u20130.60\u2009g per kg diet optimized growth performance through enhanced weight gain, feed efficiency, and nutrient digestibility, while favorably modulating cecum microbiome, serum cholesterol, liver enzyme activities, and ameliorated meat quality.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72156","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:31:53Z","timestamp":1785303113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose Titration of Plant\u2010Based Flavonoid Blend Supplementation on Performance, Digestibility, Gut Microbiome, Blood Biomarkers, and Meat Quality of Growing Rabbits"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-0693","authenticated-orcid":false,"given":"Md. Aliar","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition, Faculty of Animal Husbandry Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9992-5612","authenticated-orcid":false,"given":"Md. Mehedi","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition, Faculty of Animal Husbandry Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-3544","authenticated-orcid":false,"given":"Md. Abul","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Animal Husbandry Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7159-0747","authenticated-orcid":false,"given":"Mahbubul Pratik","family":"Siddique","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-6267","authenticated-orcid":false,"given":"Rakhi","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition, Faculty of Animal Husbandry Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25724"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2024.k848"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.24925\/turjaf.v13is3.3785\u20103794.8004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.21608\/ASSJM.2022.277820"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12202809"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.9775\/kvfd.2024.33414"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081888"},{"key":"e_1_2_11_9_1","first-page":"2005","volume-title":"Official Methods of Analysis","author":"Association of Official Analytical Chemists (AOAC)","year":"2005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14744\/ijmb.2022.96977"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13427"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2021.1889406"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e30598"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731119002283"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010023\u201000840\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjas.v51i2.60495"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12243543"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.17.0284"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.21608\/ijesr.2026.507914"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2019.114333"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781789241273.0000"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation11060346"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.12418\/CJAN2023.363"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejnf.2019.79436"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11101401"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250\u2010025\u201004313\u2010x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013\u201003585"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani9010007"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5455\/OVJ.2026.v16.i4.30"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259\u2010026\u201011111\u20109"},{"key":"e_1_2_11_31_1","unstructured":"Kazi Agro Ltd.2022.\u201cAnta Phyt Optidose.\u201dhttps:\/\/www.kaziagro.com\/17."},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020162"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.17221\/82\/2025\u2010CJAS"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.01.014"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1485065"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skaf395"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2024.107401"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.014050"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.21608\/epsj.2020.134962"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjas\u20102015\u20100132"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.4995\/wrs.2018.10435"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.20.0379"},{"key":"e_1_2_11_43_1","article-title":"Dose Titration of Herbs Mixture Powder Supplementation on Laying Performance and Egg Quality in Commercial Layer Chicken","volume":"33","author":"Rahman M. 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