{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:48Z","timestamp":1790172168210,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360620"],"award-info":[{"award-number":["82360620"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060008"],"award-info":[{"award-number":["82060008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin lesions. Mitochondrial dysregulation is associated with various pathologic conditions, including inflammation in the skin. Prior research has indicated that Erianin, a naturally occurring compound derived from Dendrobium plants, has antioxidant and anti\u2010inflammatory effects. Generally, Erianin has been demonstrated to be effective in cutaneous melanoma and ulcerative colitis. However, there is limited knowledge regarding its biological components and the mechanisms by which it prevents and treats AD. To investigate the protective effects of Erianin against AD and to elucidate the potential mechanism of inflammation in AD, with a particular focus on the role of mitochondrial impairment pathways. Combined with vivo and vitro models of inflammation was employed to assess skin conditions, oxidative stress, and mitochondrial dysfunction. The mitochondrial homeostasis was analyzed, and the effects of Erianin treatment on these processes were evaluated using histological analysis, biochemical assays, molecular techniques, and targeting inflammatory cytokines, oxidative stress, mitophagy, and apoptosis. Erianin effectively alleviated AD, and computational simulations suggested a potential interaction with PINK1. Treatment with Erianin significantly reversed these dysfunctional states by promoting mitophagy activity, thereby alleviating mitochondrial dysfunction and reducing ROS levels, which ultimately suppressed apoptosis. These findings demonstrate that Erianin exerts therapeutic potential in AD by targeting mitophagy, with PINK1\/Parkin\u2010mediated mitophagy playing a crucial role in the pathogenesis of AD.<\/jats:p>","DOI":"10.1002\/fsn3.72158","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:30:46Z","timestamp":1784957446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Erianin Targets\n                    <scp>PINK1<\/scp>\n                    \/Parkin\u2010Mediated Mitophagy and Apoptosis to Ameliorate Atopic Dermatitis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4575-9987","authenticated-orcid":false,"given":"Kexin","family":"Xu","sequence":"first","affiliation":[{"name":"Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases Yanbian University  Yanji The People's Republic of China"},{"name":"Department of 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