{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:18Z","timestamp":1791003198648,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004045","name":"Karadeniz Teknik \u00dcniversitesi","doi-asserted-by":"publisher","award":["FSI\u20102021\u20109820"],"award-info":[{"award-number":["FSI\u20102021\u20109820"]}],"id":[{"id":"10.13039\/501100004045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the anti\u2010obesity effects of water\u2010based Anatolian propolis extract in mice with a cafeteria diet\u2010induced obesity model. The phenolic composition, antioxidant capacity, and \u03b1\u2010amylase\/\u03b1\u2010glucosidase inhibitory effects of the WBAP extract were characterized in\u00a0vitro. For the in\u00a0vivo study, 42 male C57BL\/6 mice were divided into a control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096) and a study group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200936) fed a CAF diet for 12\u2009weeks. Obese mice were then treated for 4\u2009weeks with WBAP or Orlistat via intraperitoneal injection. At the end of the 28\u2010day treatment period, serum and tissues were collected. Serum levels of insulin, leptin, adiponectin, TNF\u2010\u03b1, IL\u20106, UCP\u20101, and various biochemical parameters were analyzed. Liver and adipose tissues were subjected to histopathological analysis. Compared to the untreated CAF group, the WBAP\u2010treated group exhibited significant reductions in body weight, serum triglycerides, AST, ALT, HOMA\u2010IR, leptin, and TNF\u2010\u03b1 levels. Furthermore, there was a significant increase in adiponectin levels in the WBAP\u2010treated group. Water\u2010based Anatolian propolis (WBAP) ameliorates key features of diet\u2010induced obesity, including dyslipidemia, liver damage, inflammation, and hormonal dysregulation. These results suggest that WBAP is a promising natural and alternative agent for the prevention and treatment of obesity and its related metabolic complications.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72160","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:40:00Z","timestamp":1785303600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of Water\u2010Based Anatolian Propolis Extract Against\n                    <scp>CAF<\/scp>\n                    Diet\u2010Induced Obesity and Its Metabolic Complications"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-807X","authenticated-orcid":false,"given":"Mehmet","family":"Kemal","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Karadeniz Technical University  Trabzon Turkiye"},{"name":"Graduate School of Natural and Applied Science Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-9548","authenticated-orcid":false,"given":"Elif","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-8825","authenticated-orcid":false,"given":"Ali","family":"Kulaber","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-2889","authenticated-orcid":false,"given":"Sevil","family":"K\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9617-6689","authenticated-orcid":false,"given":"Ahmet","family":"Alver","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-4394","authenticated-orcid":false,"given":"Engin","family":"Yenilmez","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-6139","authenticated-orcid":false,"given":"Sevgi","family":"Kolayl\u0131","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113187"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.31467\/uluaricilik.877301"},{"key":"e_1_2_11_4_1","first-page":"15","volume-title":"Methods in Enzymology","author":"Benzie I. 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