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In the present study, hexane\u2010extracted chia seed oil was investigated for anti\u2010obesity, hematoprotective, and hepatorenoprotective potentials in high\u2010fat diet (HFD)\u2010induced obese mice. The mice were fed a 15% butter\u2010fortified HFD to induce obesity, followed by supplementation with three chia seed oil (CSO) doses (200, 400, and 600\u2009mg\/kg body weight\/day) through custom\u2010formulated feed. For statistical comparison, three control groups were maintained: normal control, HFD control, and chia control (600\u2009mg\/kg). CSO supplementation significantly reduced body mass gain, food efficiency ratio, and visceral fat accumulation. Restoration of hematological parameters occurred in the CSO\u2010treated groups, with increased RBC, PLT, and LYM counts and elevated Hb, HCT, and PCT levels. Elevated WBC counts and altered RBC and PLT indices (MCV, MCH, RDW\u2010CV, RDW\u2010SD, MPV, PDW) were also restored toward normal levels following CSO treatment. An improvement in lipid profiles (TG, TC, LDL\u2010C, HDL\u2010C) was observed in the CSO\u2010treated groups. Furthermore, hepatic (ALT, AST, TBIL, ALP) and renal (SCr, BUN) biomarkers were significantly attenuated following CSO supplementation, approaching physiological levels. Histological evaluation of liver and kidney tissues confirmed restoration of HFD\u2010induced structural impairments. Nonsignificant variation was found between the normal control and chia control groups for most parameters. The calculated CSO doses correspond to human\u2010equivalent intake, highlighting their translational relevance. These findings suggest dose\u2010responsive anti\u2010obesity effects of CSO, along with protective effects against obesity\u2010associated hematological disturbances and hepatorenal dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72161","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:41:46Z","timestamp":1785303706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose\u2010Dependent Anti\u2010Obesity and Protective Effects of Chia (\n                    <scp>\n                      <i>Salvia hispanica<\/i>\n                    <\/scp>\n                    L.) Seed Oil Against Hematological and Hepatorenal Dysfunction in High\u2010Fat Diet\u2013Fed Mice"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-3320","authenticated-orcid":false,"given":"Sabbya","family":"Sachi","sequence":"first","affiliation":[{"name":"Department of Pharmacology Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9465-080X","authenticated-orcid":false,"given":"Mst. Prianka","family":"Jahan","sequence":"additional","affiliation":[{"name":"Department of Fisheries Technology Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9226-7744","authenticated-orcid":false,"given":"Sree Alok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8792-9397","authenticated-orcid":false,"given":"Mahmudul Hasan","family":"Sikder","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-6711","authenticated-orcid":false,"given":"Md. 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