{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:13Z","timestamp":1791003193879,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is a major public health issue associated with metabolic disturbances and alteration in the gut microbiota. Studies indicate that bioactive compounds can modulate these processes, and fruit by\u2010products represent a promising source of such compounds. This study investigated the impact of araticum (\n                    <jats:italic>Annona crassiflora<\/jats:italic>\n                    Mart.) by\u2010product on intestinal microbiota composition and obesity biomarkers in mice fed a high\u2010fat diet. The by\u2010product was characterized for technological and proximate composition. Forty\u2010six Swiss mice were randomized into four groups: a control diet group, a high\u2010fat diet group, a high\u2010fat diet + araticum by\u2010product (200\u2009mg\u2009kg\u20101) group, and a high\u2010fat diet + araticum by\u2010product (400\u2009mg\u2009kg\u20101) group. After 30\u2009days, murinometric, biochemical, and histological parameters and the composition of microbiota were assessed. The by\u2010product contained 8.04\u2009g.100\u2009g\u20101 of moisture, 11.17\u2009g.100\u2009g\u20101 of protein, 9.79\u2009g.100\u2009g\u20101 of lipids, 53.29\u2009g.100\u2009g\u20101 of total fiber (3.96\u2009g.100\u2009g\u20101 soluble and 49.33\u2009g.100\u2009g\u20101 insoluble), 2.97\u2009g.100\u2009g\u20101 of ash, and 14.74\u2009g.100\u2009g\u20101 of digestible carbohydrates. Araticum by\u2010product consumption did not affect weight gain or glucose tolerance but increased fecal moisture content and reduced pH. Regarding gut microbiota composition, the supplemented groups showed a trend toward a higher relative abundance of Firmicutes. In the group receiving the highest dose of araticum by\u2010product (400\u2009mg\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), more intense intestinal PAS staining was observed, which may indicate a greater presence of PAS\u2010positive mucin\u2010containing structures. These preliminary findings suggest that the araticum by\u2010product may influence selected intestinal parameters, although its functional effects require confirmation in longer\u2010term and mechanistic studies.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72163","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:04:27Z","timestamp":1785319467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Araticum (\n                    <i>Annona crassiflora<\/i>\n                    Mart.) By\u2010Product on Intestinal Health Parameters in High\u2010Fat Diet\u2010Fed Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Thamara Rosa","family":"de Souza","sequence":"first","affiliation":[{"name":"Faculty of Nutrition Federal University of Mato Grosso  Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fellipe Lopes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Do Estado de S\u00e3o Paulo  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Neves Casarotti","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Federal University of Rondon\u00f3polis  Rondon\u00f3polis Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-8530","authenticated-orcid":false,"given":"Su\u00e9lem Aparecida","family":"de Fran\u00e7a Lemes","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Chemical Institute  Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eudes Thiago","family":"Pereira Avila","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Mato Grosso  Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2323-008X","authenticated-orcid":false,"given":"Am\u00edlcar","family":"Sabino Damazo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Mato Grosso  Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-4534","authenticated-orcid":false,"given":"Lucas Amoroso Lopes","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Livestock and Environmental Biotechnology S\u00e3o Paulo State University (UNESP), School of Agricultural and Veterinary Sciences  Jaboticabal S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-5936","authenticated-orcid":false,"given":"Daniel","family":"Guariz Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Livestock and Environmental Biotechnology S\u00e3o Paulo State University (UNESP), School of Agricultural and Veterinary Sciences  Jaboticabal S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Sivieri","sequence":"additional","affiliation":[{"name":"Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry Food University of Araraquara (UNIARA)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-6630","authenticated-orcid":false,"given":"Maressa","family":"Caldeira Morzelle","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition Federal University of Mato Grosso  Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/299537"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/star.19700220408"},{"key":"e_1_2_10_4_1","volume-title":"FastQC: A Quality Control Tool for High Throughput Sequence Data","author":"Andrews S.","year":"2010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12071536"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.05.011"},{"key":"e_1_2_10_7_1","volume-title":"Official Methods of Analysis of AOAC International","author":"Association of Official Analytical Chemists","year":"1995"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517003282"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130\u2010014\u20100440\u2010y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S234665"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0269\u20102813.2004.01862.x"},{"key":"e_1_2_10_12_1","unstructured":"Brazil. 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