{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:18Z","timestamp":1791003198781,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Calamus guruba<\/jats:italic>\n                    Buch.\u2010Ham. (Family: Arecaceae) is a traditionally valued medicinal plant recognized for its wide range of therapeutic applications. This study was designed to evaluate the antidiabetic, anti\u2010inflammatory, anxiolytic, and antidepressant properties of the methanolic extract of\n                    <jats:italic>C. guruba<\/jats:italic>\n                    (MECG). Phytochemical screening of the extract was performed according to standard protocols. The antidiabetic potential was assessed using an alpha\u2010amylase inhibition assay. At the same time, anti\u2010inflammatory effects were examined using both in\u00a0vitro (protein denaturation) and in\u00a0vivo (carrageenan\u2010 and formalin\u2010induced paw edema) models. Anxiolytic activity was evaluated using the elevated plus maze (EPM) and hole board test (HBT), and antidepressant effects were determined through the tail suspension test (TST). MECG demonstrated potent antidiabetic activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 48.69\u2009\u03bcg\/mL. The extract also showed marked anti\u2010inflammatory effects in all tested models. MECG showed significant anxiolytic activity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in both the EPM and HBT at a dose of 400\u2009mg\/kg. Moreover, the same dose significantly decreased immobility time in the TST compared to the control group, indicating robust antidepressant\u2010like effects. Collectively, these findings suggest that MECG holds promise as a natural therapeutic agent for the management of diabetes, inflammation, anxiety, and depression.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72168","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:12:51Z","timestamp":1785395571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological Assessment of\n                    <i>Calamus guruba<\/i>\n                    Methanolic Extract: Multitarget Effects on Diabetes, Inflammation, Anxiety, and Depression"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4872-290X","authenticated-orcid":false,"given":"Mohi","family":"Uddin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0262-6046","authenticated-orcid":false,"given":"Tania Akter","family":"Shorna","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5176-5891","authenticated-orcid":false,"given":"Khurshida Jahan","family":"Suma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4676-0253","authenticated-orcid":false,"given":"Md. Ekramul Haque","family":"Ekram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5964-4566","authenticated-orcid":false,"given":"Masud","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, Faculty of Life and Earth Science Jagannath University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1926-6407","authenticated-orcid":false,"given":"Md. Jahirul Islam","family":"Mamun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1098"},{"issue":"1","key":"e_1_2_11_3_1","article-title":"Protective Effect of Bergapten Against Human Erythrocyte Hemolysis and Protein Denaturation In\u00a0Vitro","volume":"2021","author":"Aidoo D. 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