{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:21Z","timestamp":1791003201577,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer cachexia (CC) is a multifactorial metabolic syndrome characterized by systemic inflammation, muscle wasting, and adipose tissue depletion. Amaranth\n                    <jats:italic>\n                      (\n                      <jats:styled-content style=\"fixed-case\">Amaranthus caudatus<\/jats:styled-content>\n                    <\/jats:italic>\n                    L.), a pseudocereal rich in proteins, squalene, and tocotrienols, exhibits strong antioxidant and anti\u2010inflammatory activities. Enzymatic hydrolysis of amaranth proteins enhances bioavailability and physiological potency. Korean mint (\n                    <jats:italic>Agastache rugosa<\/jats:italic>\n                    ) extract, abundant in flavonoids such as tilianin and acacetin, has been reported to suppress inflammatory and oxidative pathways. However, the combined effect of amaranth hydrolysate and Korean mint extract (AKE) on cancer cachexia has not been elucidated. CT26 tumor\u2010bearing mice (six\u2010week\u2010old male BALB\/c) were orally administered AKE (125 or 250\u2009mg\/kg\/day) for 14\u2009days. AKE attenuated cachexia\u2010induced weight loss (3.6%\u201310.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and preserved muscle (13.6%\u201315.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and fat mass (36.0%\u201340.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Grip strength was significantly improved. AKE suppressed serum pro\u2010inflammatory cytokines and inhibited muscle protein degradation by downregulating muscle RING\u2010finger protein\u20101 and muscle atrophy F\u2010box expression. It also enhanced protein synthesis by activating the protein kinase B\/mammalian target of rapamycin pathway. In adipose tissue, AKE reduced AMP\u2010activated protein kinase browning while promoting adipogenesis via proliferator\u2013activated receptor gamma, CCAAT\/enhancer\u2010binding protein alpha, and Sterol regulatory element\u2010binding protein 1 upregulation. These findings demonstrate that AKE mitigates cancer\u2010induced muscle and fat loss by modulating inflammation, proteolysis, and metabolic remodeling, highlighting its potential as a multi\u2010targeted nutritional strategy for managing cancer cachexia.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72182","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:44:38Z","timestamp":1785318278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amelioration of Cancer Cachexia\u2010Induced Muscle Atrophy and Adipose Tissue Wasting by a Combination of Amaranth (\n                    <scp>\n                      <i>Amaranthus caudatus<\/i>\n                    <\/scp>\n                    L.) Hydrolysate and Korean Mint (\n                    <i>Agastache rugosa<\/i>\n                    ) Extract in\n                    <scp>BALB<\/scp>\n                    \/c Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Junhee","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate Program in Bioindustrial Engineering Yonsei University  Seoul Republic of Korea"},{"name":"Health Research Division DAESANG Wellife Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Kang","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioindustrial Engineering Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0742-1290","authenticated-orcid":false,"given":"Sungmin","family":"Han","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioindustrial Engineering Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Tak","family":"Jung","sequence":"additional","affiliation":[{"name":"Health Research Division DAESANG Wellife Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8972-6737","authenticated-orcid":false,"given":"Daedong","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Research Division DAESANG Wellife Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioindustrial Engineering Yonsei University  Seoul Republic of Korea"},{"name":"Department of Biotechnology Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-6661","authenticated-orcid":false,"given":"Jae\u2010Kwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioindustrial Engineering Yonsei University  Seoul Republic of Korea"},{"name":"Department of Biotechnology Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24173033"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153803"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26811"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/APM.2018.10.01"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010023\u201002639\u20107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539\u2010013\u20100105\u2010y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(10)70218\u20107"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103195"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16213671"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7740\/kjcs.2014.59.1.016"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010022\u201004398\u20100"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214760"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2023.101020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020183"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103735"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020502"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188821"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12162937"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/168407"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.3"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.16056"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1207746"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2021.1950175"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1724954"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14091603"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.601329"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3292087"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.597675"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2024.29.2.154"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.12.005"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1423053"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b05387"}],"container-title":["Food Science &amp; 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