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Vitamin E (VE), comprising lipid\u2010soluble tocopherols and tocotrienols, is linked to membrane protection, lipid peroxidation control, inflammatory mediator regulation, and endothelial responses. This study examined whether VE\u2010related molecular signatures converge on AIS\u2010associated redox, lipid\u2010inflammatory, vascular, and multicellular remodeling programs. Peripheral blood miRNA data (GSE235203) and bone marrow transcriptomic data (GSE110359) were integrated using HERB\u2010based compound mapping, VE\u2010AIS shared\u2010target enrichment, feature prioritization, intradisease GSEA, single\u2010cell localization, CellChat analysis, and NHANES contextualization. HERB mapping generated a VE\/tocopherol\u2010related prioritization signal, not direct evidence of VE involvement in AIS. Forty\u2010two shared VE\u2010AIS targets were enriched mainly in oxidative stress, glutathione\/peroxidase activity, and glutathione metabolism, with additional lipid\u2010inflammatory and vascular signals. Five prioritized genes (SOD1, GCLC, PTGS1, PTGS2, and KDR) defined redox\u2010buffering, lipid\u2010inflammatory, and vascular\u2010response axes. Single\u2010cell and CellChat analyses localized these signatures mainly to endothelial, dendritic\/APC\u2010like, MSC\u2010like, and stromal\/osteogenic populations, suggesting a predicted concave\u2010side enrichment of inflammatory\u2010endothelial\u2010stromal communication. Structural analyses supported the computational plausibility of \u03b1\u2010tocopherol compatibility with selected proteins, particularly PTGS2. No AIS cohort with measured VE exposure or status was analyzed. NHANES provided external clinical nutrition context rather than AIS\u2010specific validation. Overall, VE\u2010related signatures overlapped with redox, lipid\u2010inflammatory, vascular\u2010response, and multicellular remodeling programs in AIS. These findings generate testable molecular hypotheses but do not show that VE intake, tocopherol status, or supplementation modifies AIS risk, severity, or progression.<\/jats:p>","DOI":"10.1002\/fsn3.72190","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:13:18Z","timestamp":1786079598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin E\u2010Related Molecular Signatures in Adolescent Idiopathic Scoliosis: A Hypothesis\u2010Generating Multi\u2010Omics Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9152-5609","authenticated-orcid":false,"given":"Ying","family":"Ma","sequence":"first","affiliation":[{"name":"Shuguang Hospital Shanghai University of Traditional Chinese Medicine  Shanghai 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