{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:46:45Z","timestamp":1792511205461,"version":"4.5.0"},"reference-count":83,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.695630\/2022\u20100"],"award-info":[{"award-number":["88887.695630\/2022\u20100"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oxidative stress is a characteristic of obesity dysfunction\u2010associated fatty liver disease. Copaiba oil\u2010resin (Co\u2010resin) is known for its antioxidant and hepatoprotective properties; however, its effects on the oxidative system of obese rodents are unknown, particularly with regard to potential sex differences. Here, we evaluated the effects of the oral Co\u2010resin supplementation on plasma and hepatic oxidative parameters in male and female rodents with hypothalamic\u2010induced obesity. Hypothalamic obesity was induced during the early postnatal days (PND) by monosodium glutamate (MSG; 4\u2009g kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) administration, while control (CON) animals received equimolar saline solution. From 30 to 90 PND, MSG, and CON groups (both sexes) were divided into Co\u2010resin\u2010supplemented (0.5\u2009mL kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , three times a week\/8\u2009weeks) or non\u2010supplemented animals. Adiposity, plasma, and hepatic metabolic and oxidative markers were assessed. Hepatic tissue was used for histological analysis. Male and female MSG\u2010obese rats presented higher adiposity and metabolic dysfunction, associated with reductions in plasma and hepatic antioxidative activities of glutathione reductase, glutathione\u2010S\u2010transferase, and catalase. Reduced hepatic glutathione peroxidase was also observed in MSG\u2010obese rats of both sexes. Moreover, plasma, and hepatic thiobarbituric acid reactive substances and reactive species were increased in MSG\u2010obese (male and female) animals. MSG\u2010obese rats of both sexes displayed abnormal hepatic histopathology and reduced liver superoxide dismutase and catalase contents. Co\u2010resin oral supplementation effectively restored plasma and hepatic oxidative systems in MSG\u2010obese males and females without significantly adiposity change. However Co\u2010resin supplementation had more positive effects on the metabolic parameters of MSG\u2010obese females, since it restored liver structural abnormalities, plasma triglyceride levels, and insulin responsiveness.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72195","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:55:52Z","timestamp":1788861352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Copaiba Oil\u2010Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic\u2010Obese Animals"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6670-2691","authenticated-orcid":false,"given":"Sirlei P.","family":"Souza","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Bioci\u00eancia e Sa\u00fade Universidade Estadual do Oeste do Paran\u00e1  Cascavel PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-7073","authenticated-orcid":false,"given":"Zo\u00e9 M. N.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Bioci\u00eancia e Sa\u00fade Universidade Estadual do Oeste do Paran\u00e1  Cascavel PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6605-5782","authenticated-orcid":false,"given":"Beatriz M.","family":"Daudt","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Bioci\u00eancia e Sa\u00fade Universidade Estadual do Oeste do Paran\u00e1  Cascavel PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-953X","authenticated-orcid":false,"given":"Marianela A. F.","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Bioci\u00eancia e Sa\u00fade Universidade Estadual do Oeste do Paran\u00e1  Cascavel PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-1671","authenticated-orcid":false,"given":"Caroline M.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1  Toledo PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-6642","authenticated-orcid":false,"given":"Ellen C. Z.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Bioci\u00eancia e Sa\u00fade Universidade Estadual do Oeste do Paran\u00e1  Cascavel PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-6739","authenticated-orcid":false,"given":"Mustafa M. M.","family":"Dahleh","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Universidade Federal do Pampa  Uruguaiana RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-7469","authenticated-orcid":false,"given":"Marina","family":"Prigol","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Universidade Federal do Pampa  Uruguaiana RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-5348","authenticated-orcid":false,"given":"Gustavo P.","family":"Guerra","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Universidade Federal do Pampa  Uruguaiana RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-7399","authenticated-orcid":false,"given":"Lucin\u00e9ia F. 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