{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:07Z","timestamp":1791003187643,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002713","name":"Imam Mohammed Ibn Saud Islamic University","doi-asserted-by":"publisher","award":["IMSIU\u2010DDRSP2601"],"award-info":[{"award-number":["IMSIU\u2010DDRSP2601"]}],"id":[{"id":"10.13039\/501100002713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n Daucus carota<\/jats:italic>\n <\/jats:styled-content>\n subsp.\n maximus<\/jats:italic>\n , a biennial plant from the\n Apiaceae<\/jats:italic>\n family, is valued for its aromatic properties. It is the largest wild carrot subspecies found in Algeria, characterized by its tall stem, triangular leaves, and large umbels. This study aimed to characterize the phenolic profile of organic extracts of\n \n D. carota<\/jats:italic>\n <\/jats:styled-content>\n subsp.\n maximus<\/jats:italic>\n and evaluate their antioxidant, antibacterial, \u03b1\u2010amylase inhibitory, and ADME properties. The acetone extract contained the highest polyphenol content (305.17\u2009\u00b1\u20090.56\u2009\u03bcg GAE\/mg E), while the methanol extract had the highest flavonoid content (135.54\u2009\u03bcg QE\/mg E) and exhibited superior antioxidant activity across multiple assays through lower IC\n 50<\/jats:sub>\n values in the DPPH (32.67\u2009\u00b1\u20090.74\u2009\u03bcg\/mL) and ABTS (13.76\u2009\u00b1\u20090.06\u2009\u03bcg\/mL) assays, and lower\n A<\/jats:italic>\n 0.5<\/jats:sub>\n values in the CUPRAC (47.79\u2009\u00b1\u20090.12\u2009\u03bcg\/mL), phenanthroline (131.65\u2009\u00b1\u20091.38\u2009\u03bcg\/mL), potassium ferricyanide (36.34\u2009\u00b1\u20090.83\u2009\u03bcg\/mL), and SNP (92.92\u2009\u00b1\u20090.73\u2009\u03bcg\/mL) assays. Using LC\u2010ESI\u2010MS\/MS, a total of 19 phenolic compounds were detected, with rutin being the predominant one. The acetone extract exhibited marked antibacterial effects, especially against\n \n Micrococcus luteus<\/jats:italic>\n <\/jats:styled-content>\n and\n \n Pseudomonas aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n , while the hexane extract achieved the greatest \u03b1\u2010amylase inhibitory activity, reaching 52.15% at 400\u2009\u03bcg\/mL. In silico ADME analysis suggested favorable absorption profiles for several compounds and possible BBB permeability for selected molecules.\n \n D. carota<\/jats:italic>\n <\/jats:styled-content>\n subsp.\n maximus<\/jats:italic>\n exhibits significant bioactive properties, highlighting its potential applications as a source of antioxidant, antibacterial, and enzyme\u2010inhibitory agents. However, further in\u00a0vivo investigations and formulation studies are required to validate these potential applications.\n <\/jats:p>","DOI":"10.1002\/fsn3.72202","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:14:46Z","timestamp":1786428886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wild\n Daucus carota<\/i>\n Subsp.\n maximus<\/i>\n : Phytochemicals, Bioactivities, and Pharmacokinetic Insights for Future Food and Therapeutic Applications"],"prefix":"10.1002","volume":"14","author":[{"given":"Maroua","family":"Hadji","sequence":"first","affiliation":[{"name":"Biodiversity and Biotechnological Techniques for Plant Resources Valorization Laboratory (BTB_VRV), Department of Natural and Life Sciences, Faculty of Sciences University of M'sila, University Pole M'sila Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6786-7758","authenticated-orcid":false,"given":"Khadidja","family":"Dehimi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry, Faculty of Sciences University of M'sila, University Pole M'sila Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethi Farouk","family":"Kebaili","sequence":"additional","affiliation":[{"name":"University Mohamed El Bachir El Ibrahimi of Bordj Bou Arreridj El Anasser Algeria"},{"name":"Laboratory of Microbiological Engineering and Application, Biochemistry and Molecular and Cellular Biology Department, Faculty of Nature and Life Sciences University of Mentouri Brothers Constantine 1 Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahar","family":"Smaili","sequence":"additional","affiliation":[{"name":"Biodiversity and Biotechnological Techniques for Plant Resources Valorization Laboratory (BTB_VRV), Department of Natural and Life Sciences, Faculty of Sciences University of M'sila, University Pole M'sila Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5881-8426","authenticated-orcid":false,"given":"Toka","family":"Hadji","sequence":"additional","affiliation":[{"name":"Laboratory of the Development and Valorization of Plant Genetic Resources, Department of Biology and Plant Ecology University of Mentouri Brothers Constantine 1 Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larbi","family":"Derbak","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Technologies Agro\u2010Alimentaires Route de Targa Ouzemmour Bejaia Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Arts, Department of Molecular Biology and Genetics Tokat Gaziosmanpa\u015fa University Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-0396","authenticated-orcid":false,"given":"Fehmi","family":"Boufahja","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5980-391X","authenticated-orcid":false,"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek H.","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3493-6451","authenticated-orcid":false,"given":"Walid","family":"Elfalleh","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jpbs.JPBS_175_19","article-title":"Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes","volume":"1","author":"Abubakar A. 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