{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:18Z","timestamp":1791003198744,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Traditional medicine has long utilized\n                    <jats:italic>Drimycarpus racemosus<\/jats:italic>\n                    (Roxb.) Hook.f ex Marchand, which is a member of the Anacardiaceae family, to treat inflammation, pain, and metabolic disorders; however, its therapeutic properties have not been experimentally investigated. This study aimed to investigate the analgesic and hypoglycemic activities of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>D. racemosus<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaf extract and explore its bioactive constituents through a computational approach. The most prevalent chemicals found in the plant methanolic extract, according to GC\u2013MS analysis, were Furfural, 4\u2010methoxybenzoic acid, methyl ester and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sitosterol acetate. The FT\u2010IR (Fourier transform infrared spectroscopy) analysis of the extracts revealed the presence of hydroxyl, carbonyl, aromatic, aliphatic C\u2013H, and C\u2013O functional groups. Acetic acid\u2010induced writhing test, formalin\u2010induced hind paw licking test, and hot plate tests were used to assess the analgesic activity using Swiss albino mice, whereas streptozotocin (STZ)\u2010induced animals were used to assess the hypoglycemic activity. In silico docking experiments were performed using Gaussian, Gabedit, Discovery Studio, Swiss PDB Viewer, PyRx, and PyMOL tools against cyclooxygenase\u20102 (COX\u20102) and sulfonylurea receptor\u20101 (SUR\u20101), with ADME data supporting the results. The extract reduced writhing by 55.48% and 66.45% at 250 and 500\u2009mg\/kg, respectively. At 500\u2009mg\/kg, the extract significantly reduced paw licking time to 52.4\u2009\u00b1\u20095.95\u2009s during the early phase and 3.4\u2009\u00b1\u20090.51\u2009s during the late phase. At 500\u2009mg\/kg, a decrease in plasma glucose indicated hypoglycemic action.\n                    <jats:italic>In silico,<\/jats:italic>\n                    4\u2010methoxybenzoic acid, methyl ester showed the strongest affinity for COX\u20102 (\u22128.3\u2009kcal\/mol), outperforming diclofenac (\u22126.4\u2009kcal\/mol), while 4\u2010methoxybenzoic acid, methyl ester demonstrated higher binding with SUR\u20101 (\u22129.0\u2009kcal\/mol) compared to Glibenclamide (\u22128.5\u2009kcal\/mol).\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>D. racemosus<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract has substantial analgesic and hypoglycemic properties, and its phytoconstituents show promise as new medicinal research possibilities.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72204","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:14:02Z","timestamp":1785734042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative\n                    <scp>GC<\/scp>\n                    \u2013\n                    <scp>MS<\/scp>\n                    ,\n                    <scp>FT<\/scp>\n                    \u2010\n                    <scp>IR<\/scp>\n                    , and Molecular Docking Analysis of\n                    <i>Drimycarpus racemosus<\/i>\n                    (Roxb.) Hook.f ex Marchand: In\u00a0Vivo Analgesic and Antidiabetic Potential"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2252-1818","authenticated-orcid":false,"given":"Md Sajib","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1146-5312","authenticated-orcid":false,"given":"Md. Rakibul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7710-0383","authenticated-orcid":false,"given":"M. A.","family":"Rafi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2298-8961","authenticated-orcid":false,"given":"Sanjana Haque","family":"Esha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5700-5584","authenticated-orcid":false,"given":"Md. Mehedi","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4064-1503","authenticated-orcid":false,"given":"Payar","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7435-6948","authenticated-orcid":false,"given":"Abdullah","family":"Ripon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4058-8449","authenticated-orcid":false,"given":"Nilufar","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Manarat International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-92387-1_1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001136"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738\u2010081X(86)90078\u20107"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2004.02198.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470027318.a5606"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7471.867"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1462309"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","unstructured":"El\u2010Nashar H. A. S. N. M.Mostafa M.El\u2010Shazly andO. A.Eldahshan.2021.\u201cThe Role of Plant\u2010Derived Compounds in Managing Diabetes Mellitus: A Review of Literature From 2014 to 2019.\u201dhttps:\/\/www.eurekaselect.com\/article\/111729.","DOI":"10.2174\/0929867328999201123194510"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0547s70"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21111600"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e328348bf6f"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(87)90088\u20101"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.07.044"},{"key":"e_1_2_12_15_1","unstructured":"Kew Org.1869.\u201cDrimycarpus racemosus(Roxb.) 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