{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:18Z","timestamp":1791003198656,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is known to be associated with dyslipidaemia, cardiovascular disorders, oxidative stress, adipogenic and adipokine responses. The anti\u2010obesity effect of\n                    <jats:italic>Coula edulis<\/jats:italic>\n                    nut extract (CEE) was investigated in high\u2010fat\u2010diet (HFD) fed obese Wistar rats. After a four\u2010week HFD feeding, the rats received the nut extract\n                    <jats:italic>p.o<\/jats:italic>\n                    . for 5\u2009weeks in a two\u2010batch design. Batch I: Normal Control (ND only) Obese Control (HFD only), Standard Control (HFD\u2009+\u20090.03\u2009g\/kg b.w. Orlistat) and extract\u2010treated groups 1 and 2 (HFD\u2009+\u2009CEE1g\/kg b.w. and HFD\u2009+\u2009CEE2g\/kg b.w., respectively). Batch II: Normal Control (ND only), Obese Control (ND only), Standard Control (ND\u2009+\u20090.03\u2009g\/kg b.w. Orlistat) and extract\u2010treated groups 1 &amp; 2 (ND\u2009+\u2009CEE1g\/kg b.w. and ND\u2009+\u2009CEE2g\/kg b.w., respectively). During the 5\u2010week extract treatment, Batch I rats were fed HFD alongside, whereas the Batch II rats were fed normal diet (ND) instead. Weight gain, feed intake, anthropometric indicators, blood lipids, cardiovascular risk indices, pancreatic lipase activity, tissue lipid content, hepatic cholesterol biosynthesis, oxidative stress indices, expression of adipogenic\/lipogenic genes and adipose histology were determined.\n                    <jats:italic>Coula edulis<\/jats:italic>\n                    extract was found to decrease weight gain, obesity indicators, lipogenesis, pancreatic lipase activity, cardiovascular risk factors, oxidative stress, and PPAR\u2010\u03b3, C\/EBP\u2010\u03b1 and SREBP\u20101c mRNA levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090). Together, the results indicate that\n                    <jats:italic>Coula edulis<\/jats:italic>\n                    nut extract could attenuate obesity by modulating lipid digestion, cholesterol synthesis, oxidative stress and adipogenic\/lipogenic transcription factors.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72209","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:35:33Z","timestamp":1786682133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Target Anti\u2010Obesity Potential of\n                    <i>Coula edulis<\/i>\n                    Nut Extract in High\u2010Fat Diet\u2010Induced Obesity in Rats"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5162-1257","authenticated-orcid":false,"given":"Chidimma Emmanuel","family":"Ibeneme","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences University of Calabar  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-9760","authenticated-orcid":false,"given":"Item Justin","family":"Atangwho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences University of Calabar  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-7772","authenticated-orcid":false,"given":"Godwin Eneji","family":"Egbung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences University of Calabar  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9598-6919","authenticated-orcid":false,"given":"Diana Ochuole","family":"Odey","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Pharmaceutical Sciences Kampala International University in Tanzania  Dar es Salaam Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7973-3296","authenticated-orcid":false,"given":"Chinedum Ekeleme","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science Southern Delta University  Ozoro Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-2246","authenticated-orcid":false,"given":"Uket Nta","family":"Obeten","sequence":"additional","affiliation":[{"name":"Department of Chemistry\/Biochemistry and Molecular Biology Alex Ekwueme Federal University  Abakaliki Ebonyi State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8129-5698","authenticated-orcid":false,"given":"Wilson Arong","family":"Obio","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences University of Calabar  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4341-6380","authenticated-orcid":false,"given":"Louisiane Patrick","family":"Nangah","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences Top Faith University  Uyo Akwa Ibom State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-4198","authenticated-orcid":false,"given":"Emmanuel O.","family":"Ibeneme","sequence":"additional","affiliation":[{"name":"Department of Medical Bacteriology, Virology and Mycology, Faculty of Medical Laboratory Science University of Calabar  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-1785","authenticated-orcid":false,"given":"Daniel Ejim","family":"Uti","sequence":"additional","affiliation":[{"name":"Department of 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