{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:17Z","timestamp":1791003197812,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There is a history of using the medicinal plant\n                    <jats:italic>Chaetocarpus<\/jats:italic>\n                    genus, native to Southeast Asia, to treat a wide range of illnesses. The absence of detailed pharmacological validation for this plant is unexpected, considering its importance in ethnopharmacology. This study was supposed to conduct a laboratory evaluation of the pharmacological properties of the methanol extract of\n                    <jats:italic>Chaetocarpus castanocarpus<\/jats:italic>\n                    bark (MECCB). The MECCB was prepared by cold maceration and then subjected to phytochemical measurement (total phenolic, flavonoid, and tannin content) and antioxidant testing ([2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) radical scavenging]). Oral glucose tolerance tests were utilized to evaluate hypoglycemic potential, yeast\u2010induced pyrexia to measure antipyretic effects, castor oil\u2010induced diarrhea to measure antidiarrheal activity, and acetic acid\u2010induced writhing and formalin tests to evaluate analgesic effects in\u00a0vivo. The study used standard treatments, 200 and 400\u2009mg\/kg MECCB in contrast to the control group in\n                    <jats:italic>Swiss albino<\/jats:italic>\n                    mice. At 400\u2009mg\/kg, MECCB exhibited a writhing inhibition of 73.86%, demonstrating dose\u2010dependent antinociceptive effectiveness. MECCB\u2010treated groups showed a significant reduction in fever compared to the vehicle control group. A decrease of 37.06% in intestinal motility and a reduction of 58.53% in diarrheal feces were among the antidiarrheal effects. The fast drop in glucose levels (\u0394\u2009=\u20096.5\u2009mmol\/L) caused by hypoglycemia was comparable to the effects of glibenclamide. The IC50 of MECCB in the DPPH assay is 418.73\u2009\u03bcg\/mL, demonstrating its antioxidant activity. This activity is associated with the high amounts of flavonoids (280.143\u2009\u00b1\u200945.122\u2009mg QE\/g) and phenolics (364.917\u2009\u00b1\u200927.0159\u2009mg GAE\/g) present. MECCB's potential as a natural medication is supported by its positive effects on pain relief, fever reduction, diarrhea treatment, and glucose regulation. Additional research is needed to identify active compounds and elucidate their mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72221","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:29:03Z","timestamp":1786944543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Chaetocarpus castanocarpus<\/i>\n                    Bark Extract Alleviates Pain, Pyrexia, Diarrhea, Hyperglycemia, and Oxidative Stress: Evidence From Integrated In\u00a0Vitro and In\u00a0Vivo Studies"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3161-3136","authenticated-orcid":false,"given":"Rakibur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3255-6156","authenticated-orcid":false,"given":"Farjana Akter","family":"Nipa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimun","family":"Siddique","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6248-6378","authenticated-orcid":false,"given":"Tania","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abed Foyez","family":"Rafi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Alfesani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1149-6821","authenticated-orcid":false,"given":"Ziaul","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1924-5132","authenticated-orcid":false,"given":"Tuhin Chandra","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-3977","authenticated-orcid":false,"given":"Riniara","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-5491","authenticated-orcid":false,"given":"Abdur","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Swabi  Swabi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan A.","family":"Hemeg","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.11.051"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2017.10.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2023.100459"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010021\u201003290\u20106"},{"key":"e_1_2_9_6_1","first-page":"471","article-title":"Antithrombotic and Thrombolytic Activity of Terminalia Belerica Fruit Extracts","volume":"3","author":"Ansari V.","year":"2012","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"Asao T. andM.Asaduzzaman.2018.\u201cPhytochemicals: Source of Antioxidants and Role in Disease Prevention. 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