{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:04Z","timestamp":1791003184037,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Phillyrin (PHI), a major dietary lignan derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Forsythia suspensa<\/jats:italic>\n                    <\/jats:styled-content>\n                    , is a neuroprotective bioactive compound. This study investigated the protective effects of PHI against D\u2010galactose (D\u2010gal)\u2010induced memory decline in mice and explored the underlying mechanisms, focusing on neuroinflammation mediated by Toll\u2010like receptor 4 (TLR4) and nuclear factor kappa B (NF\u2010\u03baB). In\u00a0vivo, mice were assigned to control, D\u2010gal, and PHI treatment groups. Behavioral performance, hippocampal histopathology, oxidative stress, inflammatory markers, and related protein expression were evaluated. In\u00a0vitro, HT22 cells exposed to D\u2010gal were treated with PHI, TAK\u2010242, or both, and analyzed for TLR4\/NF\u2010\u03baB proteins by Western blotting (WB). PHI attenuated cognitive impairment, reduced neuroinflammation, and preserved synaptic structure. Moreover, PHI downregulated TLR4, p\u2010I\u03baB\u03b1, and p\u2010NF\u2010\u03baB expression both in hippocampal tissue and HT22 cells, consistent with the effects of the TLR4 inhibitor TAK\u2010242. These findings suggest that PHI exerts neuroprotective and anti\u2010inflammatory effects via TLR4\/NF\u2010\u03baB modulation, highlighting its potential as a dietary bioactive compound to support cognitive health during aging.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72241","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:30:08Z","timestamp":1786167008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phillyrin Alleviates Memory Impairment in D\u2010Galactose\u2010Induced Aged Mice by Suppressing Hippocampal Neuroinflammation via the\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-6945","authenticated-orcid":false,"given":"Xuemin","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health Shanxi Medical University  Taiyuan Shanxi PR China"},{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Shanxi Medical University  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College of Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Huo","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxiu","family":"Bian","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfei","family":"Bai","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Shanxi Province  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Hao","sequence":"additional","affiliation":[{"name":"Taiyuan Iron and Steel (Group) co., Ltd. General Hospital  Taiyuan Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.04.041"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-04695-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8219"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"478","article-title":"HPLC\u2010Tandem Mass Spectrometric Analysis of the Marker Compounds in Forsythiae Fructus and Multivariate Analysis","volume":"53","author":"Cho H. 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L.Wang C.Li et\u00a0al.2023. \u201cPhillyrin Ameliorates Oxidative Stress in D\u2010Galactose\u2010Induced Senescence in the Brain of Mice by Regulating the Nrf2.\u201d18 no.5:1934578X231173237.","DOI":"10.1177\/1934578X231173237"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112960"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.003"},{"issue":"11","key":"e_1_2_11_24_1","first-page":"789","article-title":"The Effects of Myricitrin and Vitamin E Against Reproductive Changes Induced by D\u2010Galactose as an Aging Model in Female Mice","volume":"17","author":"Omidi M.","year":"2019","journal-title":"International Journal of Reproductive Biomedicine"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155952"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0775-z"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.640"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.04.043"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00022-6"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7108604"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115938"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190459"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.08.040"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126463"},{"issue":"1","key":"e_1_2_11_35_1","first-page":"37","article-title":"Study on Anti\u2010Aging Effects of Phillyrin on Aging Model Mice","volume":"26","author":"Yan L. 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