{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:11Z","timestamp":1791003191921,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the effect of sulforaphane\u2010producing\n                    <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                    CCFM1221 on the hepatoprotective efficacy of broccoli seed extract (BSE) in lipopolysaccharide (LPS)\u2010treated mice. The results indicate that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. paracasei<\/jats:italic>\n                    <\/jats:styled-content>\n                    CCFM1221 exhibits a high metabolic capacity for glucoraphanin. The co\u2010administration of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. paracasei<\/jats:italic>\n                    <\/jats:styled-content>\n                    CCFM1221 and BSE could ameliorate liver index, serum biochemical indicators, and hepatic inflammatory cytokines by inhibiting the TLR4\/NF\u2010\u03baB pathway and activating the Nrf2 pathway. Compared with BSE alone, the combined intervention significantly suppressed the elevation of alanine transaminase (ALT), alkaline phosphatase (ALP), interleukin (IL\u20101\u03b2), and MDA levels. Furthermore, the combination of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. paracasei<\/jats:italic>\n                    <\/jats:styled-content>\n                    CCFM1221 and BSE enhanced colonic sulforaphane levels from 195.63\u2009\u00b1\u200929.60 to 265.70\u2009\u00b1\u200934.29\u2009nmol\/g compared with BSE intervention alone. In addition, it elevated the abundance of short\u2010chain fatty acids (SCFAs)\u2010producing bacteria and promoted the growth of sulforaphane\u2010producing bacteria. These findings suggest that probiotics can enhance the activity of natural products, augmenting their pharmacological effects.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72271","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:34:31Z","timestamp":1787639671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sulforaphane\u2010Producing\n                    <i>Lacticaseibacillus paracasei<\/i>\n                    <scp>CCFM1221<\/scp>\n                    Combining Broccoli Seed Extract Improved the Hepatoprotective Effect on Lipopolysaccharide\u2010Treated Mice"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-3075","authenticated-orcid":false,"given":"Xin","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food 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