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A total of 25 crossbreed boars (LW\n                    <jats:sub>S<\/jats:sub>\n                    \u2009\u00d7\u2009Pn)\u2009\u00d7\u2009(L\n                    <jats:sub>D<\/jats:sub>\n                    \u2009\u00d7\u2009LW\n                    <jats:sub>D<\/jats:sub>\n                    ) were used in this study. All boars were genotyped for c.1423G\u2009&gt;\u2009A. The pigs were divided into two different dietary treatment groups with 0% (C\u2014control;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912) and 8.2% (E\u2014experimental;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) dried Jerusalem artichoke tubers, which were fed 14\u2009days before slaughter. The results suggest that feeding Jerusalem artichoke decreased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0236) the level of skatole in adipose tissue. In feces, a decrease in the skatole level was observed, but there was no statistically significant difference between the control and experimental groups. The influence of polymorphism on skatole levels in adipose tissue and feces were lowest for the\n                    <jats:italic>AA<\/jats:italic>\n                    genotype and highest for the\n                    <jats:italic>GG<\/jats:italic>\n                    genotype. Differences between genotypes for skatole levels in feces were statistically significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0242). Differences between genotypes in adipose tissue on skatole levels showed the same trend in favor of the\n                    <jats:italic>A<\/jats:italic>\n                    allele. However, these differences were not statistically significant. This study also confirmed the significant effect of Jerusalem artichoke on the liver\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    mRNA expression. The\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    gene expression level was significantly higher in the experimental group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0086). No significant differences in mRNA expression between different genotypes were detected.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72272","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:03:14Z","timestamp":1788498194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <scp>\n                      <i>CYP2E1<\/i>\n                    <\/scp>\n                    Polymorphism and Dietary Supplementation With Jerusalem Artichoke on Skatole and Indole Levels in the Back Fat and Feces of Boars, and Liver\n                    <scp>mRNA<\/scp>\n                    Expression"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-201X","authenticated-orcid":false,"given":"Kate\u0159ina","family":"Zadinov\u00e1","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton\u00edn","family":"Stratil","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Ecology Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic  Lib\u011bchov Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"\u010c\u00edtek","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Okrouhl\u00e1","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-2353","authenticated-orcid":false,"given":"Jan","family":"Calta","sequence":"additional","affiliation":[{"name":"Department of Genetics and Breeding, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bahelka","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Urbancov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague Czech 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