{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:49:51Z","timestamp":1792511391847,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cisplatin (CDDP) is a widely used chemotherapeutic agent, but its nephrotoxic side effects limit its clinical application, which can lead to severe acute kidney injury (AKI). Growing evidence indicates that ferroptosis plays a critical role in CDDP\u2010AKI. Rosmarinic acid (RA) is a natural polyphenolic compound extracted from various plants that has been demonstrated to possess significant antioxidant and anti\u2010inflammatory activities. This study aims to investigate whether RA protects against CDDP\u2010AKI by regulating ferroptosis. We demonstrated that RA significantly ameliorated renal dysfunction, pathological damage, and inflammatory responses in CDDP\u2010AKI mice. Furthermore, RA effectively suppressed ferroptosis by regulating the Nrf2\/HO\u20101 signaling axis, as evidenced by reduced lipid peroxidation levels and restored expression of key ferroptosis\u2010related proteins (GPX4 and xCT). Integrating network pharmacology predictions with molecular docking, we identified FYN as a potential direct target of RA and further verified that RA inhibits the expression and activation of FYN. Additionally, pharmacological inhibition of FYN using Saracatinib in\u00a0vivo or genetic knockdown of FYN in HK\u20102 cells effectively alleviated CDDP\u2010induced renal tubular injury and lipid metabolic dysregulation. In conclusion, our findings indicate that RA alleviates CDDP\u2010AKI by targeting FYN to regulate the ferroptosis pathway, highlighting that RA is a promising candidate for preventing and treating CDDP\u2010AKI.<\/jats:p>","DOI":"10.1002\/fsn3.72281","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:43Z","timestamp":1787836723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosmarinic Acid Alleviates Cisplatin\u2010Induced Acute Kidney Injury by Targeting\n                    <scp>FYN<\/scp>\n                    to Regulate Ferroptosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Chan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology and Immunology Children's Hospital of Soochow University  Suzhou Jiangsu People's Republic of China"},{"name":"Department of Nephrology, National Clinical Research Center for Children and 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