{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:18Z","timestamp":1791003198757,"version":"4.1.0"},"reference-count":106,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172214"],"award-info":[{"award-number":["32172214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972079"],"award-info":[{"award-number":["31972079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sea buckthorn (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Hippophae rhamnoides<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.) is a medicinal and edible plant rich in polyphenols, vitamins, fatty acids, carotenoids, and polysaccharides. These constituents are associated with antioxidant, anti\u2010inflammatory, hepatoprotective, gut microbiota\u2010modulating, antibacterial, and other health\u2010related activities, supporting its potential use in functional foods, nutraceuticals, pharmaceuticals, and cosmetics. However, its composition and bioactivity vary with plant part, extract type, and processing method, which complicates comparison across studies. This review evaluates sea buckthorn as a food\u2010derived functional resource by integrating evidence on its bioactive compounds, biological mechanisms, processing technologies, safety considerations, and food applications. Unlike reviews mainly summarizing phytochemical profiles or individual bioactivities, this review adopts a component\u2013matrix\u2013function perspective, emphasizing plant\u2010part specificity, extract\u2010dependent compositional variation, and translational relevance. Current evidence suggests promising application potential, although standardized preparations, quality markers, and clinically relevant studies are still needed to support evidence\u2010based utilization.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72289","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:56:55Z","timestamp":1787641015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Components and Functional Applications of Sea Buckthorn: A Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3815-5541","authenticated-orcid":false,"given":"Xiaogang","family":"Guo","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang University of Science &amp; Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laifeng","family":"Zhuo","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang University of Science &amp; Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Feng","sequence":"additional","affiliation":[{"name":"Wushi Yuanmai Agriculture Forestry and Animal Husbandry Industry Development Co., Ltd  Aksu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6972-3899","authenticated-orcid":false,"given":"Menghui","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang University of Science &amp; Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Ninh","family":"Le","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou China"},{"name":"Institute of Biotechnology and Food Technology Thai Nguyen University of Agriculture and Forestry  Thai Nguyen Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-9269","authenticated-orcid":false,"given":"Haiying","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang University of Science &amp; Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11814\u2010023\u20101453\u20108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf802599f"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.11.045"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9030269"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2023.02.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142146"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010369n"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11020545"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/jfbc\/8887109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2018.02.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105973"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12101985"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2963"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.130921"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13386"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2021.1943429"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1637676"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u2010153X\u20106\u2010106"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0955\u20102863(02)00179\u20101"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750\u20103841.17301"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034099"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14071223"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b04682"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i7.1615"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18178986"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010265"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103841.2008.00957.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3155"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpe.12947"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11105\u2010022\u201001338\u20106"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6fo01873d"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.15376\/biores.16.3.4743\u20104751"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03147C"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602831"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.118901"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.07.010"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2022.9250043"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27020523"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11203278"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1045347"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132420"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109506"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1018557"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11030462"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2024.127838"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1869921"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217\u2010020\u201003660\u20103"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11243412"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/f14122461"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262110396"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1244300"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007\u2010131\u20101728\u2010HSCALF"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.15376\/biores.17.1.527\u2010542"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082345"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2fo30125c"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/horticulturae10020137"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202101133"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010009\u20109043\u2010x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113434"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.32604\/phyton.2023.042723"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10915"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10040804"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf040241g"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2025.103849"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf072510j"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118648"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.21603\/2308\u20104057\u20102019\u20101\u201067\u201073"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.17143"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010019\u20101065\u20109"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13116513"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144429"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102835"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125784"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117809"},{"key":"e_1_2_11_76_1","doi-asserted-by":"crossref","unstructured":"Terechuk L. K.Starovoytova S.Ivanova andI.Sergeeva.2019.\u201cObtaining Functional Products From Sea Buckthorn Berries. Proceedings of the 2nd International Conference on Education Science and Social Development (ESSD 2019).\u201dhttps:\/\/doi.org\/10.2991\/essd\u201019.2019.90.","DOI":"10.2991\/essd-19.2019.90"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2019.02.024"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.09.057"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127382"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125766"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142623"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.861097"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1036295"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1067813"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1497047"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11203273"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13223665"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105511"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1430768"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.12691\/jfnr\u20102\u201012\u201027"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.860362"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2024.116171"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924\u20102244(02)00136\u2010X"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127626"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2025.465885"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2004.10.016"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12199\u2010018\u20100739\u20107"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142591"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01351"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b05306"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00399D"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13121829"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.10.002"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750\u20103841.70748"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010019\u20100224\u20102"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14183203"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.143428"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.72289","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:11:56Z","timestamp":1791000716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.72289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":106,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/fsn3.72289"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.72289","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72289"}}