{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:10Z","timestamp":1791003190855,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study examined whether\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ginkgo biloba<\/jats:italic>\n                    <\/jats:styled-content>\n                    (GB), used as an adjunct to acetazolamide (Az) for acute mountain sickness (AMS) prevention, affected endurance and cognitive performance under normobaric hypoxia in male mountaineers. This randomized, double\u2010blind, placebo\u2010controlled crossover trial included four sessions and two supplementation phases (GB and placebo) separated by a 1\u2010week washout period. Testing was conducted under normobaric hypoxic conditions (13% O\n                    <jats:sub>2<\/jats:sub>\n                    ). Twelve healthy male mountaineers (aged 18\u201344) with prior high\u2010altitude experience (above 4000\u2009m), a history of AMS, and regular aerobic training were included. Participants received GB (200\u2009mg\/day) or a placebo for 5\u2009days, with Az (125\u2009mg, three doses) administered during the final 2\u2009days of each phase. GB supplementation was associated with a significantly longer time to exhaustion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019) and lower ratings of perceived exertion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020) during treadmill exercise to exhaustion under hypoxia. However, no significant between\u2010condition differences were observed for the Feeling Scale, Felt Arousal Scale, heart rate, or peripheral oxygen saturation during the endurance test. No significant differences were found in choice reaction time or Stroop Color\u2010Word Test outcomes. In conclusion, GB supplementation for 5\u2009days was associated with a longer time to exhaustion under simulated altitude in male mountaineers using Az for AMS prevention, while no significant between\u2010condition differences were observed in cognitive outcomes. The endurance finding is preliminary and should be regarded as exploratory pending confirmation in larger studies. Because Az was administered in both conditions, the effect of GB without Az cannot be determined from this design.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    The trial was registered in the Iranian Clinical Trial Registry (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.irct.behdasht.gov.ir\">www.irct.behdasht.gov.ir<\/jats:ext-link>\n                    , IRCT ID: IRCT20230711058744N1)\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72290","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:39:40Z","timestamp":1787546380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <i>Ginkgo biloba<\/i>\n                    on Endurance and Cognitive Performance in Male Mountaineers Under Normobaric Hypoxia After Acetazolamide Treatment"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1454-0926","authenticated-orcid":false,"given":"Sara","family":"Mansouri","sequence":"first","affiliation":[{"name":"Exercise Metabolism and Performance Lab (EMPL), Department of Exercise Physiology, Faculty of Sport Sciences Razi University  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-5006","authenticated-orcid":false,"given":"Vahid","family":"Tadibi","sequence":"additional","affiliation":[{"name":"Exercise Metabolism and Performance Lab (EMPL), Department of Exercise Physiology, Faculty of Sport Sciences Razi University  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100331"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.08.052"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2012.02.006"},{"issue":"2","key":"e_1_2_13_5_1","first-page":"125","article-title":"The Acute Effect of \n                     Ginkgo biloba\n                   Extract on Muscle Soreness Markers and C\u2010Reactive Protein (CRP) After High Intensity Interval Training (HIIT) in Active Girls","volume":"13","author":"Atashak S.","year":"2021","journal-title":"Sport Physiology & Management Investigations"},{"key":"e_1_2_13_6_1","volume-title":"Neuropsychological Evaluation of the Child: Domains, Methods, & Case Studies","author":"Baron I. S.","year":"2018"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1770063"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00589.2024"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1191058"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1147860"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-113011-143750"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.14215"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001731"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868\u2010023\u201000794\u20104"},{"key":"e_1_2_13_15_1","volume-title":"European Union Herbal Monograph on Ginkgo biloba L., Folium","author":"European Medicines Agency\u2010Committee on Herbal Medicinal Products (HMPC)","year":"2015"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.12.022"},{"key":"e_1_2_13_17_1","volume-title":"Simple Stroop Software","author":"Khodadadi M.","year":"2014"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122319"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118297"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000002346"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.2021137"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2023.05.013"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2012.12.009"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.109.2.163"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.106.1.163-170"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2016.0001"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology13100835"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280585"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080803"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-025-00409-x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12010015"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00767-8"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2012.12.003"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507075205"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/f14122284"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155352"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.72290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:13:04Z","timestamp":1791000784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.72290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/fsn3.72290"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.72290","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72290"}}