{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:49:30Z","timestamp":1792511370599,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ergothioneine (EGT) is a naturally occurring sulfur\u2010containing histidine derivative with antioxidant and anti\u2010inflammatory properties. However, its protective role and potential mechanisms in intestinal inflammation remain insufficiently understood. The impact of EGT on colitis was assessed in the present study using two experimental systems: an LPS\u2010induced inflammatory model in Caco\u20102 cells and a DSS\u2010induced colitis model in mice. In\u00a0vitro, Caco\u20102 cells were treated with LPS and different concentrations of EGT, followed by assessment of inflammatory cytokines and tight junction\u2010related markers using ELISA, qRT\u2010PCR, and immunofluorescence staining. In\u00a0vivo, DSS\u2010induced colitis mice received low\u2010, medium\u2010, or high\u2010dose EGT, and disease activity, colon histopathology, serum inflammatory mediators, immunoglobulins, and gut microbiota composition were analyzed. EGT treatment attenuated LPS\u2010induced inflammatory responses in Caco\u20102 cells and partially restored the expression and distribution of tight junction proteins, including ZO\u20101, Occludin, and Claudin\u20101. In DSS\u2010induced colitis mice, EGT alleviated body weight loss, reduced disease activity index scores, improved colon shortening and histological injury, and decreased serum levels of TNF\u2010\u03b1, IL\u20106, IL\u20101\u03b2, IgM, and IgA. Moreover, EGT partially reversed DSS\u2010induced gut microbiota dysbiosis. Notably, high\u2010dose EGT was associated with the enrichment of\n                    <jats:italic>Lachnospiraceae NK4A136<\/jats:italic>\n                    group and\n                    <jats:italic>Enterorhabdus<\/jats:italic>\n                    , suggesting that these taxa may contribute to EGT\u2010mediated microbiota remodeling. Collectively, these findings indicate that EGT may alleviate experimental colitis through coordinated regulation of intestinal barrier integrity, inflammatory responses, and gut microbiota composition, supporting its potential as a functional food ingredient for intestinal inflammatory disorders.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72294","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:26:11Z","timestamp":1789107971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multi\u2010Target Approach to Colitis: Ergothioneine Promotes Recovery by Restoring the Intestinal Barrier, Reducing Inflammation, and Remodeling the Microbiota"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0162-8571","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"College of Food Science Northeast 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