{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:59:15Z","timestamp":1790405955961,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272775"],"award-info":[{"award-number":["32272775"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470566"],"award-info":[{"award-number":["32470566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In clinic, once the ovulated oocytes cannot be fertilized timely, they begin to undergo post\u2010ovulatory aging, which impacts the embryo development and offspring health. Until now, there are no better methods to delay post\u2010ovulatory oocyte aging. Epigallocatechin gallate (EGCG) is the most abundant bioactive component of tea polyphenols that are beneficial for alleviating the deleterious influence of environmental factors on oocyte quality. In the present study, we examined the role of EGCG in delaying oocyte aging after ovulation in\u00a0vitro. Ovulated oocytes were treated with EGCG at different concentrations, and the fragmentation rate, induced by aging, was significantly reduced by EGCG at 50\u2009\u03bcM in\u00a0vitro. To further elucidate the influence of EGCG on the quality of post\u2010ovulatory aged oocytes, we examined the spindle morphology of aged oocytes. The results showed that EGCG significantly decreased the abnormal rate of spindle morphology in post\u2010ovulatory aged oocytes. The high level of reactive oxygen species (ROS) and mitochondrial dysfunction in post\u2010ovulatory aged oocytes were also improved by EGCG, which might be a reason for the reduced apoptosis. The reduced sperm binding capacity of aged oocytes was increased by the addition of EGCG. These suggest that EGCG can improve the quality of post\u2010ovulatory aged oocytes.<\/jats:p>","DOI":"10.1002\/fsn3.72324","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:07:46Z","timestamp":1788592066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigallocatechin Gallate From Tea Delays Oocyte Aging After Ovulation in Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Jing","family":"Lin","sequence":"first","affiliation":[{"name":"College of Horticulture Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Science Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Life Science Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Fan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Horticulture Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Life Science Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Wen","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Life Science Sichuan Agricultural University  Ya'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Lvliang First People's Hospital, Lvliang Hospital of Shanxi Medical University  Lvliang China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, School of Life Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-6675","authenticated-orcid":false,"given":"Zhao\u2010Jia","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Horticulture Qingdao Agricultural University  Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1591672"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114267"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01045-6"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2015.08.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040929"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"105","article-title":"Oocyte Quality and Aging","volume":"26","author":"Eftekhari M. 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