{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:59:16Z","timestamp":1790405956498,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["2024106620616"],"award-info":[{"award-number":["2024106620616"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Coix seed is a medicinal and nutritional resource, but its protective effects against acute lung injury (ALI) remain unclear. This study investigated the efficacy, active components, and mechanisms of Coix seed extract (CSE) against ALI, focusing on the NLRP3 signaling pathway. The therapeutic efficacy of CSE was evaluated in a murine model of ALI. Liquid chromatography\u2010mass spectrometry identified 32 components in CSE, which were then analyzed via network pharmacology, molecular docking, and molecular dynamics simulations for target prediction and drug\u2010likeness evaluation. In\u00a0vivo effects on NLRP3 pathway proteins were also examined. CSE decreased serum levels of TNF\u2010\u03b1 and IL\u20101\u03b2, pulmonary levels of IL\u20101\u03b2 and IL\u201018, indicating systemic and local inflammatory suppression. Furthermore, CSE downregulated the expression of NLRP3, Caspase\u20101, and GSDMD\u2010N in lung tissues, suggesting inhibition of NLRP3 inflammasome\u2010driven pyroptosis. Network analysis screened 35 core targets and 4 NLRP3\u2010related key targets involved in pathways regulating inflammation, proliferation, and oxidative stress. Molecular docking and dynamics simulations further corroborated the \u201ccomponent\u2010target\u2010disease\u201d interactions within this network. Drug\u2010likeness evaluation identified 12 promising compounds, including syringaldehyde, tangeretin, and eriodictyol. Collectively, these findings demonstrate that CSE alleviates ALI by suppressing both inflammation and pyroptosis through multiple pathways, with NLRP3 as a central mechanistic hub. The identification of bioactive compounds with favorable pharmacokinetic properties provides a chemical basis for quality control and supports potential application of CSE as a functional food ingredient in the management of pulmonary inflammatory conditions.<\/jats:p>","DOI":"10.1002\/fsn3.72327","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:07:54Z","timestamp":1788757674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coix Seed Attenuates Acute Lung Injury via\n                    <scp>NLRP3<\/scp>\n                    Signaling Pathway: Efficacy, Active Components, and Mechanisms"],"prefix":"10.1002","volume":"14","author":[{"given":"Qi","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 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