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Wight &amp; Arn, a medicinal tree, is extensively utilized in traditional Ayurvedic medicinal systems due to its pharmacological properties, predominantly anti\u2010inflammatory, antioxidant, immune\u2010modulatory, and cardio\u2010protective. However, its therapeutic potential in the management of ulcerative colitis (UC) is relatively less explored; therefore, this review was conducted to extensively evaluate the effect of\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    and its phytoconstituents, like flavonoids, tannins, and triterpenoids, in the management of UC. Preclinical studies reveal that\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    extracts and bioactive compounds, notably arjunolic acid, attenuate colonic inflammation by modulating inflammatory cytokines, antioxidant defense, restoring mucosal barrier integrity, and gut microbiota composition. Moreover, its cyto\u2010protective and free\u2010radical scavenging activities further enhance its adequacy for gastro\u2010protection. Furthermore, the pharmacological attributes suggest that it can play a promising role in food\u2010based interventions and gut\u2010health targeted products, significantly contributing to lowering inflammation. It is reported that\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    \u2010enriched food products are effective towards plant\u2010based, natural therapies for chronic disorders, particularly UC. Despite various studies targeting its medicinal roles, the gastro\u2010protective and anti\u2010colitis potential of\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    remains clinically underexplored, with preclinical evidence providing a promising but incomplete foundation. This review provides insights into existing data on therapeutic effects of\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    in the management of UC and gastrointestinal health.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72329","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:17:42Z","timestamp":1790140662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological Activities, Medicinal Uses, and Nutritional Effects of\n                    <i>Terminalia arjuna<\/i>\n                    (Roxb. ex\n                    <scp>DC<\/scp>\n                    .) Wight &amp; Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management\u2014A Detailed Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8664-3305","authenticated-orcid":false,"given":"Rameen","family":"Naeem","sequence":"first","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7555","authenticated-orcid":false,"given":"Muhammad Tauseef","family":"Sultan","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usman","family":"Khalid","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"},{"name":"Department of Food Sciences, Faculty of Food, Nutrition and Home Sciences GIFT University Gujranwala  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2254-4256","authenticated-orcid":false,"given":"Muhammad","family":"Maaz","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0388-3482","authenticated-orcid":false,"given":"Ayman","family":"Furqan","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiba","family":"Tanvir","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-6628","authenticated-orcid":false,"given":"Fabiano","family":"Travaglia","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-9843","authenticated-orcid":false,"given":"Matteo","family":"Bordiga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. 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