{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:59:15Z","timestamp":1790405955754,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clear cell renal cell carcinoma (ccRCC) is characterized by substantial metabolic and molecular heterogeneity, but the disease\u2010relevant programs associated with acteoside, a dietary polyphenol, remain poorly understood. We integrated predicted acteoside targets with bulk, single\u2010cell, and spatial transcriptomic data from ccRCC and combined molecular subtyping with cross\u2010cohort machine\u2010learning analysis. Acteoside\u2010related signatures were preferentially enriched in malignant compartments and increased with tumor grade and stage. Consensus clustering identified two molecular subtypes with distinct biological and clinical features. C1 was associated with immune activation, metabolic activity, and more favorable survival, whereas C2 showed greater genomic instability, reduced renal epithelial differentiation, and poorer outcomes. We further benchmarked multiple machine\u2010learning strategies and established a 10\u2010gene prognostic model that retained predictive performance across independent cohorts, with IMPDH1 emerging as the strongest risk\u2010associated feature. Functional experiments confirmed the biological relevance of IMPDH1: its knockdown suppressed ccRCC cell proliferation, DNA synthesis, colony formation, and migration, whereas overexpression produced the opposite effects. Together, these findings indicate that acteoside\u2010related molecular signatures capture clinically relevant heterogeneity in ccRCC and provide a framework for linking dietary\u2010polyphenol\u2010related molecular space with tumor biology. The identification and functional validation of IMPDH1 further highlight its potential importance in ccRCC progression.<\/jats:p>","DOI":"10.1002\/fsn3.72340","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:48:31Z","timestamp":1788418111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Polyphenol Acteoside\u2010Related Molecular Signatures in Clear Cell Renal Cell Carcinoma: Multi\u2010Omics Profiling and Functional Validation of\n                    <scp>IMPDH1<\/scp>"],"prefix":"10.1002","volume":"14","author":[{"given":"Xu","family":"Chen","sequence":"first","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-1351","authenticated-orcid":false,"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Ji","sequence":"additional","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"Sun","sequence":"additional","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-8142","authenticated-orcid":false,"given":"Shuijie","family":"Shen","sequence":"additional","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9211-4270","authenticated-orcid":false,"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nantong Hospital of Traditional Chinese Medicine Clinical Innovation Research Center, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"},{"name":"Clinical Medical Research Center, Nantong Hospital of Traditional Chinese Medicine, Affiliated Traditional Chinese Medicine Hospital of Nantong University Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.11.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-00983-w"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv5457"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","unstructured":"Cardinali A. 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