{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:41:54Z","timestamp":1791837714239,"version":"4.3.4"},"reference-count":100,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Plant flavonoids are polyphenolic compounds widely found in fruits, vegetables, tea, legumes, and medicinal and edible plants; they are important natural functional components in food. These compounds play a significant role in various biological activities, such as alleviating inflammation, regulating insulin sensitivity, and improving glucose and lipid metabolism, making them ideal candidates for the development of functional foods and dietary intervention strategies aimed at balancing endocrine and metabolic functions. This paper first systematically reviews the dietary sources and distribution of plant flavonoids, their structural classification, and the factors determining their intestinal metabolism and bioavailability; it then summarizes the key molecular mechanisms and experimental studies regarding the intervention of plant flavonoids in polycystic ovary syndrome (PCOS). Building on this foundation, from the practical perspective of functional food development, the paper focuses on the application of modern food processing technologies\u2014such as microencapsulation, nano\u2010encapsulation, liposomal carriers, enzymatic hydrolysis and fermentation, and synergistic effects with excipients\u2014in enhancing the bioavailability of plant flavonoids. It analyzes technical approaches for regulating stability and sensory quality in formulation design and proposes practical dietary strategies and personalized nutrition plans for individuals with PCOS. Finally, future research directions for flavonoid dietary interventions are outlined, aiming to provide guidance for the research, development, and commercialization of functional foods containing plant flavonoids, and to promote the food industry's transition toward precision nutrition and personalized health interventions.<\/jats:p>","DOI":"10.1002\/fsn3.72350","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:58:07Z","timestamp":1789711087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plant Flavonoid\u2014Enriched Functional Foods for Polycystic Ovary Syndrome: Dietary Sources, Bioavailability Enhancement, and Personalized Intervention Strategies"],"prefix":"10.1002","volume":"14","author":[{"given":"Jianding","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"},{"name":"Laboratory of Food Nutrition and Clinical Research, Institute of Seafood Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Food Nutrition and Clinical Research, Institute of Seafood Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-0182","authenticated-orcid":false,"given":"Qing","family":"Shen","sequence":"additional","affiliation":[{"name":"Laboratory of Food Nutrition and Clinical Research, Institute of Seafood Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunli","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxi","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Mao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Yao","sequence":"additional","affiliation":[{"name":"Quzhou Hospital of Traditional Chinese Medicine (Four\u2010Province Bordering Hospital), Zhejiang Chinese Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Panvascular Diseases Research Center The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital  Quzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Quzhou Hospital of Traditional Chinese Medicine (Four\u2010Province Bordering Hospital), Zhejiang Chinese Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Xu","sequence":"additional","affiliation":[{"name":"Panvascular Diseases Research Center The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital  Quzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Traceability and Efficacy Research of Genuine Medicinal Materials Hangzhou Linping Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11072078"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010025\u201010579\u2010z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.70039"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102162"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2026.1767453"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2018.1446146"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092901"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010020\u201003351\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084110"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10112701"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.10.029"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666181101110050"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/app142411954"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30112376"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.65"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.136051"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1917508"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010061121\u2010090535"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12244"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox15050539"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7624932"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1706084"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010025\u201004774\u20105"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121967"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2018.04.002"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.081"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103095"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amolm.2024.100048"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118590263.ch10"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2014.1003649"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101298331"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70101"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2090893"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00034.2021"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5202908"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42859"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42074"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5555315"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S490836"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuae101"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308\u20108146(01)00114\u20105"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5c00097"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162750"},{"key":"e_1_2_12_46_1","unstructured":"Laaksonen O.n.d.\u201cAstringent Food Compounds and Their Interactions with Taste Properties.\u201d"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327120954521"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3233\/NUA\u20102012\u20100002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.330S"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24338"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030167"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.09.003"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010019\u201009650\u2010y"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1591534"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo01437h"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12241"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1065243"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S443692"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1294406"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2018.04.008"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160720155855"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2024.11.015"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125135"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094\u2010020\u201000161\u20108"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13071103"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2281641"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab181"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.11.008"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv029"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa051"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113947"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1704814"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c07198"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27206854"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2176817"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2024.1768"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071944"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010118705"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8428"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo03283f"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1153289"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493895"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43043\u2010023\u201000142\u2010w"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390601062054"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/HM9.0000000000000192"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2025.1602967"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010023\u201004736\u2010w"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad096"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1947772"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4579831"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398109527312"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113286"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1232129"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2024.100728"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010025\u201006260\u2010w"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2025.102342"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12173315"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194128"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010026\u201011901\u2010z"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6678398"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2024.104723"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.72350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:20:51Z","timestamp":1790403651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.72350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":100,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/fsn3.72350"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.72350","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72350"}}