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Among them,\n                    <jats:italic>Terminalia arjuna<\/jats:italic>\n                    stands out as a widely consumed dietary and Ayurvedic remedy. This review explores the pharmacological evidence for\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    and its relevance to food science and toxicology, unveiling its molecular mechanisms in health and disease. They target the axis of p53\u2010PARP mediated apoptosis, endoplasmic reticulum stress mechanisms, mitochondrial integrity, and TGF\u2010\u03b2 mediated remodeling processes.\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    's major bioactive constituents like arjunic acid, arjunolic acid, and casuarinin, to name a few, possess antioxidant, anti\u2010inflammatory, cardioprotective, renal, and liver\u2010protective capacities. In this work, we critically evaluate the strength of preclinical versus clinical evidence and identify the gaps in bioavailability, safety, and herb\u2010drug interaction data, beyond its pharmacological profile, to establish\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    's translational potential. This study further explores\n                    <jats:italic>T. arjuna<\/jats:italic>\n                    as a candidate for modern nutraceutical and functional food development while highlighting the need for future validations before its full potential is confirmed.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72352","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:57:08Z","timestamp":1790686628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Harnessing\n                    <i>Terminalia arjuna<\/i>\n                    in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health"],"prefix":"10.1002","volume":"14","author":[{"given":"Ishani","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Biotechnology Manipal School of Life Sciences, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahika","family":"Nazeerulla","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Manipal School of Life Sciences, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-0024","authenticated-orcid":false,"given":"Manash Kumar","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology and Toxicology Manipal School of Life Sciences, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-3354","authenticated-orcid":false,"given":"Sujit Kumar","family":"Bhutia","sequence":"additional","affiliation":[{"name":"Department of Life Science National Institute of Technology Rourkela  Rourkela India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deblina","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Microbiology New York University (NYU) Langone Health  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-8694","authenticated-orcid":false,"given":"Subhadip","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Manipal School of Life Sciences, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120232"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121856"},{"key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/B978-0-323-85542-6.00011-1","volume-title":"Evidence\u2010Based Validation of Herbal Medicine (Second Edition)","author":"Alam M. 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